Camu F, Heytens L, Claeys M A
Acta Anaesthesiol Belg. 1985 Dec;36(4):381-9.
The present study was undertaken to assess the intensity and duration of analgesic effect of ciramadol during induction and maintenance of general anesthesia for short surgical procedures. Sixty female patients received either ciramadol 2 mg.kg-1 or saline before anesthesia induction with thiopental-succinylcholine followed by enflurane maintenance. The changes in heart rate following intubation and surgical incision were partially obtunded by ciramadol pretreatment but mean arterial pressure remained significantly elevated till 6 min. post surgical incision. No evidence of impairment of the spontaneous ventilation was observed even when enflurane anesthesia was added. Addition of enflurane also had no deleterious effects on the cardiovascular performance in the ciramadol treatment group. In the absence of pretreatment with ciramadol, the higher concentrations of enflurane needed induced a significantly lower blood pressure but the rise in heart rate observed remained notably larger than in the ciramadol group. This was accompanied by a reduction of spontaneous ventilation as evidenced by the decrease of minute volume. With both techniques end-tidal carbon dioxide tensions rose to the same extent. Maintenance of adequate anesthesia required a larger amount of enflurane in the non-pretreated group. This could indicate an anesthesia sparing effect of ciramadol.
本研究旨在评估环拉马朵在短时间外科手术全身麻醉诱导和维持期间的镇痛效果强度及持续时间。60名女性患者在硫喷妥钠-琥珀酰胆碱诱导麻醉前，分别接受2mg.kg-1环拉马朵或生理盐水，随后用安氟醚维持麻醉。环拉马朵预处理部分减轻了插管和手术切口后心率的变化，但平均动脉压在手术切口后6分钟内仍显著升高。即使加用安氟醚麻醉，也未观察到自主通气受损的迹象。在环拉马朵治疗组中，加用安氟醚对心血管功能也无有害影响。在未用环拉马朵预处理的情况下，所需的较高浓度安氟醚导致血压显著降低，但观察到的心率升高仍明显大于环拉马朵组。这伴随着分钟通气量减少所证明的自主通气减少。两种技术下呼气末二氧化碳分压升高程度相同。在未预处理组中，维持足够的麻醉需要更多的安氟醚。这可能表明环拉马朵具有麻醉节省作用。
