Clinical Laboratory, Quzhou Hospital of Chinese Traditional Medicine, Quzhou, Zhejiang, 324000, China.
Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, China.
Future Microbiol. 2024;19(18):1529-1534. doi: 10.1080/17460913.2024.2406122. Epub 2024 Oct 9.
Japanese spotted fever (JSF) is an emerging acute febrile natural infectious disease caused by the neglected zoonotic pathogen . Here we reported a 64-year-old female patient who initially presented to the local hospital with an intermittent fever of unknown origin (FUO). A systemic, evident edema and eschar on the skin of the patient's upper limb was observed. The patient was diagnosed with critical bloodstream infection by Q-mNGS and treated with doxycycline, as well as symptomatic treatments. Unfortunately, the patient passed away as a result of complications of septic shock and multiple organ and acute respiratory failure. Delayed treatment resulting from the nonspecific clinical symptoms in the early stages of infection can lead to fatal complications. Q-mNGS is an emerging pathogen detection method with the advantages of comprehensive detection, high accuracy and sensitivity and should be promoted and applied by clinicians.
日本斑点热（JSF）是一种由被忽视的人畜共患病原体引起的新兴急性发热性自然传染性疾病。在这里，我们报告了一例 64 岁女性患者，她最初因不明原因的发热待查（FUO）到当地医院就诊。患者上肢皮肤可见全身性、明显的水肿和焦痂。通过 Q-mNGS，该患者被诊断为严重的血流感染，给予多西环素和对症治疗。不幸的是，患者因感染性休克和多器官及急性呼吸衰竭的并发症而死亡。由于感染早期的非特异性临床症状，延迟治疗可能导致致命的并发症。Q-mNGS 是一种新兴的病原体检测方法，具有全面检测、高准确性和灵敏度的优点，应得到临床医生的推广和应用。
