Wang Haoyi, Ni Zhen, Chang Yinghao
Department of Infectious Disease, The General Hospital of Western Theater Command, Chengdu, 610083 People's Republic of China.
Infect Drug Resist. 2024 Nov 14;17:5073-5077. doi: 10.2147/IDR.S483309. eCollection 2024.
Japanese spotted fever (JSF) is a neglected and potentially fatal infectious disease. Delays in diagnosis and treatment of JSF are important causes of poor prognosis. We report a case of JSF in a 75-year-old farmer who, following autumn field work in Sichuan, China, presented with an atypical triad of clinical symptoms: high fever, petechial rash, and notably no eschar. Without appropriate diagnosis and treatment, she developed septic shock and acute respiratory distress syndrome. The diagnosis of JSF was confirmed by the identification of by metagenomic next-generation sequencing (mNGS) of the blood. After one week of treatment with doxycycline, the patient's clinical symptoms subsided without any complaints of discomfort.
日本斑点热（JSF）是一种被忽视的潜在致命性传染病。JSF诊断和治疗的延迟是预后不良的重要原因。我们报告一例75岁农民患JSF的病例，该患者在中国四川秋季田间劳作后，出现非典型的三联临床症状：高热、瘀点皮疹，且明显无焦痂。未经适当诊断和治疗，她发展为感染性休克和急性呼吸窘迫综合征。通过对血液进行宏基因组下一代测序（mNGS）鉴定，确诊为JSF。经多西环素治疗一周后，患者临床症状消退，无任何不适主诉。
