Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha 410008, P. R. China.
Department of Prosthodontics, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha 410008, P. R. China.
J Mater Chem B. 2024 Nov 6;12(43):11063-11075. doi: 10.1039/d4tb01589d.
Bacterial infection severely limits the effectiveness of biomaterials for tissue repair, posing a major challenge to modern medicine. Despite advances in novel antibiotics and their application in treatment, challenges remain in clinical practice. To address this issue, biomaterials are engineered to achieve desirable anti-infective performance and compatibility adjusting their surface physicochemical properties. Recently, numerous studies on piezoelectric materials have been performed for anti-infective and regenerative therapies, but a comprehensive review is still lacking. This article provides a brief overview of the different types of piezoelectric materials and their characteristics. Building on this understanding, this review highlights the antibacterial mechanisms including orchestrating electric field and optimizing piezoelectric catalysis, which promote infective tissue regeneration, as well as discusses the anti-infective bioapplication of piezoelectric materials. Furthermore, this review concludes with perspectives into the challenges and future research directions of piezoelectric biomaterials.
细菌感染严重限制了生物材料在组织修复方面的效果，这对现代医学构成了重大挑战。尽管新型抗生素的应用在治疗方面取得了进展，但在临床实践中仍然存在挑战。为了解决这个问题，生物材料被设计为实现理想的抗感染性能和兼容性，调整其表面物理化学性质。最近，针对抗感染和再生治疗的压电材料研究有很多，但仍缺乏全面的综述。本文简要概述了不同类型的压电材料及其特性。在此基础上，本文重点介绍了包括调控电场和优化压电催化在内的抗菌机制，这些机制促进了感染组织的再生，并讨论了压电材料的抗感染生物应用。此外，本文还展望了压电生物材料的挑战和未来研究方向。
