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无原发灶的肠道绒毛膜癌:诊断之谜。

Intestinal choriocarcinoma without primary source: A diagnostic enigma.

机构信息

Department of General Surgery, Manisa Celal Bayar University, Manisa-Türkiye.

Department of Obstetrics and Gynecology, Manisa Celal Bayar University, Manisa-Türkiye.

出版信息

Ulus Travma Acil Cerrahi Derg. 2024 Oct;30(10):771-773. doi: 10.14744/tjtes.2024.57242.

DOI:10.14744/tjtes.2024.57242
PMID:39382358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11622712/
Abstract

Intestinal choriocarcinoma is a very rare phenomenon. This is the first reported case of intestinal choriocarcinoma following an ectopic pregnancy. We report a 24 year-old woman who presented with severe abdominal pain, distension, and vomiting. She had a history of an ectopic pregnancy nine months prior. Emergent laparotomy exploration revealed abscess formation and obstructions at two sites in the small intestine, with unremarkable gynecological organs. The obstructed sections of the intestinal were excised and subsequently diagnosed as intestinal choriocarcinoma in histopathological evaluation. Postoperative positron emission tomography (PET) revealed a non-contrast-enhancing lesion on the small intestinal wall with increased metabolic activity consistent with healing tissue at the anastomosis site. No other primary focus and/or metastatic lesions were detected. Multi-agent chemotherapy was planned for the patient. No residual and/or recurrent tumoral lesions were detected on the PET scan at the one-year follow-up.

摘要

肠绒毛膜癌是一种非常罕见的现象。这是首例报道的宫外孕后继发肠绒毛膜癌。我们报告了一例 24 岁女性,因剧烈腹痛、腹胀和呕吐就诊。她在 9 个月前有过宫外孕病史。急诊剖腹探查显示在小肠的两个部位形成脓肿并发生梗阻,妇科器官无明显异常。梗阻的肠段被切除,组织病理学评估诊断为肠绒毛膜癌。术后正电子发射断层扫描(PET)显示小肠壁上有一个非增强性病变,伴有吻合部位愈合组织的代谢活性增加。未发现其他原发病灶和/或转移病灶。计划为患者进行多药物化疗。在一年的随访时,PET 扫描未发现残留和/或复发性肿瘤病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ee/11622712/cfeb4a7943a7/TJTES-30-771-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ee/11622712/1411aaa65d64/TJTES-30-771-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ee/11622712/cfeb4a7943a7/TJTES-30-771-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ee/11622712/1411aaa65d64/TJTES-30-771-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ee/11622712/cfeb4a7943a7/TJTES-30-771-g002.jpg

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1
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本文引用的文献

1
Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: A Society of Gynecologic Oncology evidenced-based review and recommendation.妊娠滋养细胞疾病的流行病学、诊断与治疗:妇科肿瘤学会循证综述与推荐
Gynecol Oncol. 2021 Dec;163(3):605-613. doi: 10.1016/j.ygyno.2021.10.003. Epub 2021 Oct 20.
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Gestational trophoblastic neoplasia presenting as an interstitial ectopic pregnancy.以间质部异位妊娠形式表现的妊娠滋养细胞肿瘤
Gynecol Oncol Rep. 2021 Jun 21;37:100813. doi: 10.1016/j.gore.2021.100813. eCollection 2021 Aug.
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A rare case of gestational trophoblastic neoplasia following an ectopic molar pregnancy.
一例罕见的异位葡萄胎妊娠后发生的妊娠滋养细胞肿瘤。
Gynecol Oncol Rep. 2021 May 30;37:100798. doi: 10.1016/j.gore.2021.100798. eCollection 2021 Aug.
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Obstet Gynecol. 2021 Feb 1;137(2):355-370. doi: 10.1097/AOG.0000000000004240.
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Abnormal Presentation of Choriocarcinoma and Literature Review.绒毛膜癌的异常表现及文献综述
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Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis.患有混合性生殖细胞肿瘤且伴有亚临床肠道转移的患者,因单纯转移性绒毛膜癌导致大量上消化道出血。
Urology. 2009 Feb;73(2):443.e15-7. doi: 10.1016/j.urology.2008.02.044. Epub 2008 Apr 14.
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Role of surgery in the management of high-risk gestational trophoblastic neoplasia.手术在高危妊娠滋养细胞肿瘤管理中的作用。
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10
The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment.2000年国际妇产科联盟(FIGO)妊娠滋养细胞疾病分期及危险因素评分系统:描述与批判性评估
Int J Gynecol Cancer. 2001 Jan-Feb;11(1):73-7. doi: 10.1046/j.1525-1438.2001.011001073.x.