Department of Medical Gastroenterology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Department of Radiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Indian J Med Res. 2024 May;159(5):494-501. doi: 10.25259/ijmr_769_22.
Background & objectives Acute pancreatitis (AP) is a well known gastrointestinal cause of hospital admissions. There is a proven association between the severity of AP and obesity due to increased rates of local complications, multiple organ failure and mortality. Increased visceral adiposity is reported to be a better predictor of severe pancreatitis than body mass index (BMI) in many studies. This study aimed to assess the relationship between visceral adiposity and the severity of AP by measuring the visceral adipose tissue (VAT) area. Methods This single-centre, prospective study was conducted on consecutive individuals admitted with AP. The severity of AP was correlated with the VAT area, as estimated between 48 and 72 h of admission. Results Seventy-four individuals with AP were recruited during the study period. The overall study cohort's mean±SD for VAT area was 128.06±34.22 cm2. The VAT area was significantly larger in individuals with severe pancreatitis (141.01±33.75cm2) than in those with mild or moderate pancreatitis (115.11±29.85 cm2). The sensitivity, specificity and area under the receiver operating characteristics (AUROC) of VAT were 78.4 per cent, 54.1 per cent and 0.722 in predicting severe AP, respectively. Interpretation & conclusions There is a significant association between severe AP and VAT. With the worldwide increase in obesity incidences, incorporating VAT into one of the prognostic indices for AP needs to be further explored.
急性胰腺炎（AP）是一种常见的胃肠道疾病，可导致住院。由于局部并发症、多器官衰竭和死亡率增加，AP 的严重程度与肥胖之间存在已证实的关联。许多研究表明，内脏脂肪过多比身体质量指数（BMI）更能预测重症胰腺炎。本研究旨在通过测量内脏脂肪组织（VAT）面积来评估内脏脂肪与 AP 严重程度之间的关系。
这是一项单中心前瞻性研究，对连续入院的 AP 患者进行研究。在入院后 48 至 72 小时内，将 AP 的严重程度与 VAT 面积相关联。
在研究期间，共招募了 74 名 AP 患者。总体研究队列的 VAT 面积平均值±标准差为 128.06±34.22cm2。重症胰腺炎患者的 VAT 面积（141.01±33.75cm2）明显大于轻度或中度胰腺炎患者（115.11±29.85 cm2）。VAT 预测重症 AP 的敏感性、特异性和受试者工作特征曲线（ROC）下面积分别为 78.4%、54.1%和 0.722。
重症 AP 与 VAT 之间存在显著关联。随着肥胖发生率在全球范围内的增加，将 VAT 纳入 AP 的预后指标之一需要进一步探索。
