College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.
Chem Commun (Camb). 2024 Oct 29;60(87):12694-12697. doi: 10.1039/d4cc04312j.
The supramolecular palladium complex G-Pd, formed self-assembly of the Pd-complex of guanidinium pillar[5]arene with Pd, was used to encapsulate doxorubicin to form G-Pd@DOX. The nanoparticles exhibit responsiveness to glutathione, controlled drug release, the ability to damage mitochondria, and potent anticancer activity while maintaining low toxicity towards normal cells. This work provides a good example for the application of pillararene-based palladium complexes in cancer therapy and is significant for the discovery of new medicines from supramolecular coordination complexes.
超分子钯配合物 G-Pd 是由胍基柱[5]芳烃与钯的钯配合物自组装形成的，用于包裹阿霉素形成 G-Pd@DOX。这些纳米粒子对谷胱甘肽具有响应性，能够控制药物释放，损伤线粒体，并具有强大的抗癌活性，同时对正常细胞保持低毒性。这项工作为基于杯芳烃的钯配合物在癌症治疗中的应用提供了一个很好的例子，对于从超分子配位化合物中发现新药具有重要意义。
