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基于二硒桥联[5]轮芳烃二聚体的肿瘤微环境响应超分子糖基纳米囊泡用于靶向化疗。

Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy.

机构信息

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China.

出版信息

Chem Commun (Camb). 2020 Sep 15;56(73):10642-10645. doi: 10.1039/d0cc04149a.

DOI:10.1039/d0cc04149a
PMID:32766652
Abstract

Supramolecular glyco-nanovesicles (SeSe-(P5)2⊃Man-NH3+) based on the host-guest complex of a diselenium-bridged pillar[5]arene dimer and a mannose derivative have been successfully developed for the first time, which possessed tumor microenvironment-responsiveness and specific targetability due to their diselenium bonds and mannose units, respectively.

摘要

首次成功开发了基于二硒桥联[5]芳烃二聚体和甘露糖衍生物主客体配合物的超分子糖纳米囊泡（SeSe-（P5）2⊃Man-NH3+），由于其二硒键和甘露糖单元，分别具有肿瘤微环境响应性和特异性靶向性。

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