锯齿状息肉的危险因素：一项基于结肠镜检查的大型多中心研究结果
Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study.
作者信息
Crockett Seth D, Shaukat Aasma, Delau Olivia, Stoffel Elena M, Church Timothy R, Syngal Sapna, Bresalier Robert
机构信息
Division of Gastroenterology and Hepatology, Oregon Health & Science University and Portland VA Medical Center, Portland, Oregon, USA.
Division of Gastroenterology, NYU Grossman School of Medicine, New York, New York, USA.
出版信息
Am J Gastroenterol. 2024 Dec 1;119(12):2532-2539. doi: 10.14309/ajg.0000000000003035. Epub 2024 Sep 4.
INTRODUCTION
Risk factors for serrated polyps (SPs) are not well understood.
METHODS
Multivariable analyses of data from a multicenter colonoscopy-based study estimated odds ratios for having either a sessile serrated lesion or traditional serrated adenoma according to participant characteristics.
RESULTS
Six thousand seventy-eighty participants were included in the analyses (565 with either a sessile serrated lesion or traditional serrated adenoma). White race was associated with a higher risk of SPs compared with Black race (adjusted odds ratio 4.64, 95% confidence interval 1.89-11.41). Obesity and current smoking were also associated with a higher risk of SPs.
DISCUSSION
White race, smoking, and obesity are risk factors for precancerous SPs.
引言
锯齿状息肉（SPs）的风险因素尚未完全明确。
方法
基于一项多中心结肠镜检查研究的数据进行多变量分析，根据参与者特征估计患有无蒂锯齿状病变或传统锯齿状腺瘤的比值比。
结果
6078名参与者纳入分析（565名患有无蒂锯齿状病变或传统锯齿状腺瘤）。与黑人相比，白人患SPs的风险更高（调整后的比值比为4.64，95%置信区间为1.89 - 11.41）。肥胖和当前吸烟也与患SPs的风险较高有关。
讨论
白人、吸烟和肥胖是癌前SPs的风险因素。
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