Division of Gastroenterology, Department of Medicine, NYU Langone Grossman School of Medicine, New York, New York.
Department of Biostatistics, Fred Hutchinson Cancer Center, Seattle, Washington.
Clin Gastroenterol Hepatol. 2022 Nov;20(11):2650-2652.e1. doi: 10.1016/j.cgh.2021.09.013. Epub 2021 Sep 20.
Prior studies have reported the prevalence of colorectal cancer (CRC) in average-risk screening population ages 50-75 to be 0.7%-1.0%. However, no estimates from studies enrolling individuals undergoing screening colonoscopy have been reported. The experience of ongoing studies enrolling average-risk individuals is that the prevalence rates are substantially lower. A 2020 study from a community-based cohort undergoing CRC screening with fecal immunochemical testing followed by diagnostic colonoscopy reported a CRC prevalence rate of 1.46 per 1000, or 0.15%. The aim of our study is to report the screen-detected prevalence of CRC and advanced neoplasia in average-risk asymptomatic individuals from selected academic and community medical centers in the United States, Canada, and Germany and describe associated risk factors.
先前的研究报告称，50-75 岁平均风险筛查人群的结直肠癌（CRC）患病率为 0.7%-1.0%。然而，目前还没有研究招募接受筛查结肠镜检查的个体的相关数据。正在进行的招募平均风险个体的研究经验表明，患病率要低得多。2020 年，一项来自社区队列的研究显示，进行 CRC 筛查时使用粪便免疫化学检测，然后进行诊断性结肠镜检查，CRC 的患病率为每 1000 人中有 1.46 例，即 0.15%。我们的研究旨在报告在美国、加拿大和德国的选定学术和社区医疗中心中，平均风险无症状个体的筛查检出 CRC 和高级别瘤变的患病率，并描述相关的危险因素。
