• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

感染流感病毒后，牙买加果蝠会产生稳定且高度中和的抗体反应。

Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection.

机构信息

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.

Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.

出版信息

Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2413619121. doi: 10.1073/pnas.2413619121. Epub 2024 Oct 9.

DOI:10.1073/pnas.2413619121
PMID:39382992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11494324/
Abstract

Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.

摘要

抗体是许多物种抗病毒反应的重要组成部分，但迄今为止，尚无确凿证据表明蝙蝠能够产生强大的体液免疫反应，包括中和抗体。在这里，我们报告说，感染牙买加果蝠的甲型流感病毒 H18N11 会引发快速而稳定的体液免疫反应，具有很强的中和能力，并且在重复挑战感染后没有可检测到的病毒脱落。因此，蝙蝠的中和抗体反应可能在蝙蝠免疫中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f26/11494324/01d0aecb9e3b/pnas.2413619121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f26/11494324/1844e83a7634/pnas.2413619121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f26/11494324/01d0aecb9e3b/pnas.2413619121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f26/11494324/1844e83a7634/pnas.2413619121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f26/11494324/01d0aecb9e3b/pnas.2413619121fig02.jpg

相似文献

1
Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection.感染流感病毒后，牙买加果蝠会产生稳定且高度中和的抗体反应。
Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2413619121. doi: 10.1073/pnas.2413619121. Epub 2024 Oct 9.
2
Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.解析在单细胞水平上对雄性牙买加果蝠中 H18N11 流感病毒的感染动态。
Nat Commun. 2024 May 27;15(1):4500. doi: 10.1038/s41467-024-48934-6.
3
Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome.不同但非独特：通过研究牙买加果蝠的病毒组来解读其免疫力
Viruses. 2022 Jan 25;14(2):238. doi: 10.3390/v14020238.
4
Characterization of Experimental Oro-Nasal Inoculation of Seba's Short-Tailed Bats () with Bat Influenza A Virus H18N11.实验性经口鼻腔接种短尾突颅果蝠（）与甲型流感病毒 H18N11 的特性。
Viruses. 2020 Feb 19;12(2):232. doi: 10.3390/v12020232.
5
Bat influenza viruses transmit among bats but are poorly adapted to non-bat species.蝙蝠流感病毒在蝙蝠之间传播，但对非蝙蝠物种的适应性很差。
Nat Microbiol. 2019 Dec;4(12):2298-2309. doi: 10.1038/s41564-019-0556-9. Epub 2019 Sep 16.
6
Bats generate lower affinity but higher diversity antibody responses than those of mice, but pathogen-binding capacity increases if protein is restricted in their diet.蝙蝠产生的亲和力较低但多样性较高的抗体反应优于小鼠，但如果限制蛋白质在其饮食中，病原体结合能力会增加。
PLoS Biol. 2024 Sep 24;22(9):e3002800. doi: 10.1371/journal.pbio.3002800. eCollection 2024 Sep.
7
Serological evidence of influenza A viruses in frugivorous bats from Africa.来自非洲食果蝙蝠的甲型流感病毒血清学证据。
PLoS One. 2015 May 12;10(5):e0127035. doi: 10.1371/journal.pone.0127035. eCollection 2015.
8
Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.蝙蝠肺上皮细胞对人源和禽源流感病毒的先天固有抵抗力比 MDCK 细胞更强。
Virol J. 2018 Apr 10;15(1):68. doi: 10.1186/s12985-018-0979-6.
9
Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets.蝙蝠流感 H18N11 病毒神经氨酸酶样蛋白的突变增强了病毒在哺乳动物细胞、小鼠和雪貂中的复制。
J Virol. 2020 Feb 14;94(5). doi: 10.1128/JVI.01416-19.
10
Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis.蝙蝠体液免疫及其在病毒发病机制、传播和人畜共患病中的作用。
Front Immunol. 2024 Aug 2;15:1269760. doi: 10.3389/fimmu.2024.1269760. eCollection 2024.

引用本文的文献

1
Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology.多样的宿主，多样的免疫系统：蝙蝠免疫学的进化变异
Ann N Y Acad Sci. 2025 Aug;1550(1):151-172. doi: 10.1111/nyas.15395. Epub 2025 Jul 3.
2
Jamaican fruit bats' competence for Ebola but not Marburg virus is driven by intrinsic differences.牙买加果蝠对埃博拉病毒而非马尔堡病毒的易感性是由内在差异驱动的。
Nat Commun. 2025 Mar 25;16(1):2884. doi: 10.1038/s41467-025-58305-4.

本文引用的文献

1
Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.解析在单细胞水平上对雄性牙买加果蝠中 H18N11 流感病毒的感染动态。
Nat Commun. 2024 May 27;15(1):4500. doi: 10.1038/s41467-024-48934-6.
2
Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2.转导人 ACE2 的牙买加果蝠（Artibeus jamaicensis）对 SARS-CoV-2 的调节性 T 细胞样反应。
PLoS Pathog. 2023 Oct 19;19(10):e1011728. doi: 10.1371/journal.ppat.1011728. eCollection 2023 Oct.
3
Lessons from the host defences of bats, a unique viral reservoir.
从蝙蝠这一独特的病毒储存库的宿主防御中吸取教训。
Nature. 2021 Jan;589(7842):363-370. doi: 10.1038/s41586-020-03128-0. Epub 2021 Jan 20.
4
Novel Insights Into Immune Systems of Bats.蝙蝠免疫系统的新见解。
Front Immunol. 2020 Jan 24;11:26. doi: 10.3389/fimmu.2020.00026. eCollection 2020.
5
Characterization of Experimental Oro-Nasal Inoculation of Seba's Short-Tailed Bats () with Bat Influenza A Virus H18N11.实验性经口鼻腔接种短尾突颅果蝠（）与甲型流感病毒 H18N11 的特性。
Viruses. 2020 Feb 19;12(2):232. doi: 10.3390/v12020232.
6
Bat influenza viruses transmit among bats but are poorly adapted to non-bat species.蝙蝠流感病毒在蝙蝠之间传播，但对非蝙蝠物种的适应性很差。
Nat Microbiol. 2019 Dec;4(12):2298-2309. doi: 10.1038/s41564-019-0556-9. Epub 2019 Sep 16.
7
Bat Influenza A(HL18NL11) Virus in Fruit Bats, Brazil.巴西果蝠中的甲型流感病毒（HL18NL11）。
Emerg Infect Dis. 2019 Feb;25(2):333-337. doi: 10.3201/eid2502.181246.
8
Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats.抗体介导的病毒中和作用不是埃及果蝠清除马尔堡病毒、埃博拉病毒或 Sosuga 病毒的普遍机制。
J Infect Dis. 2019 May 5;219(11):1716-1721. doi: 10.1093/infdis/jiy733.
9
The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.埃及果蝠基因组揭示了蝙蝠抗病毒免疫的意外特征。
Cell. 2018 May 17;173(5):1098-1110.e18. doi: 10.1016/j.cell.2018.03.070. Epub 2018 Apr 26.
10
Antibody Responses to Marburg Virus in Egyptian Rousette Bats and Their Role in Protection against Infection.埃及果蝠中针对马尔堡病毒的抗体反应及其在预防感染中的作用。
Viruses. 2018 Feb 10;10(2):73. doi: 10.3390/v10020073.