Yildiz Tasci Yelda, Icoz Mehmet, Gurturk Icoz Sule Gokcek, Saritas Ozge, Arikan Yorgun Mucella, Toklu Yasin
Department of Ophthalmology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.
Department of Ophthalmology, Yozgat City Hospital, Yozgat, Turkey.
Cutan Ocul Toxicol. 2024 Dec;43(4):328-334. doi: 10.1080/15569527.2024.2408683. Epub 2024 Oct 9.
To determine the effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc in healthy participants.
This prospective design study was conducted with 27 healthy healthcare workers who received the first dose of Sinovac vaccine and 25 healthy controls who were not vaccinated. In the vaccinated group, ophthalmological examinations and measurements were performed before vaccination and one week and one month after vaccination. Subfoveal, nasal, and temporal choroidal thicknesses (CTs), retinal nerve fiber layer (RNFL) thickness, and macular thickness (MT) were determined using spectral domain-optical coherence tomography at all visits. Superficial, deep, and peripapillary radial capillary plexus (superficial capillary plexus, deep capillary plexus (DCP), and radial peripapillary capillary, respectively), choriocapillaris vascular density, and foveal avascular zone parameters were measured on optical coherence tomography-angiography (OCT-A).
No significant difference was detected between the two groups in terms of the parameters measured by OCT and OCT-A ( > 0.05 for all). The CT values measured in all quadrants were significantly higher at the first week after vaccination ( < 0.05 for all), and they returned to their pre-vaccination values at the first month post-vaccination measurement ( > 0.05 for all). Concerning the RNFL and MT values, there was no significant difference between the pre-vaccination and post-vaccination first-week measurements ( > 0.05 for all), but a statistically significant increase was detected in the post-vaccination first-month MT and RNFL measurements ( < 0.05 for all). Only the decreases in the foveal DCP and choriocapillaris vascular density values were significant at the first week after vaccination ( < 0.05 for all).
The early changes detected after vaccination in this study suggest the possibility that autoimmune, vascular, and inflammatory diseases may simultaneously emerge in the early post-vaccination period or may be triggered after vaccination, or that the vaccine may unmask these diseases.
确定接种科兴疫苗首剂对健康受试者视网膜、脉络膜和视盘的影响。
本前瞻性设计研究纳入了27名接种科兴疫苗首剂的健康医护人员和25名未接种疫苗的健康对照者。在接种疫苗组中，于接种前、接种后1周和1个月进行眼科检查和测量。在所有访视时，使用光谱域光学相干断层扫描测定黄斑中心凹下、鼻侧和颞侧脉络膜厚度（CT）、视网膜神经纤维层（RNFL）厚度和黄斑厚度（MT）。在光学相干断层扫描血管造影（OCT-A）上测量浅表、深层和视乳头周围放射状毛细血管丛（分别为浅表毛细血管丛、深层毛细血管丛（DCP）和视乳头周围放射状毛细血管）、脉络膜毛细血管血管密度和黄斑无血管区参数。
两组在OCT和OCT-A测量的参数方面均未检测到显著差异（所有参数均>0.05）。接种后第1周所有象限测量的CT值均显著更高（所有参数均<0.05），且在接种后第1个月测量时恢复到接种前值（所有参数均>0.05）。关于RNFL和MT值，接种前和接种后第1周测量之间无显著差异（所有参数均>0.05），但在接种后第1个月的MT和RNFL测量中检测到有统计学意义的增加（所有参数均<0.05）。仅接种后第1周黄斑DCP和脉络膜毛细血管血管密度值的降低具有显著性（所有参数均<0.05）。
本研究中接种疫苗后检测到的早期变化提示，自身免疫性、血管性和炎性疾病可能在接种后早期同时出现或在接种后被触发，或者疫苗可能使这些疾病显现出来。
