Ankara Yıldırım Beyazıt University, Department of Ophthalmology, Ankara City Hospital, Department of Ophthalmology, Ankara, Turkey.
Ankara Yıldırım Beyazıt University, Department of Ophthalmology, Ankara City Hospital, Department of Ophthalmology, Ankara, Turkey.
Photodiagnosis Photodyn Ther. 2023 Sep;43:103702. doi: 10.1016/j.pdpdt.2023.103702. Epub 2023 Jul 8.
To evaluate the effects of Sinovac-Coronavac and Pfizer-BioNTech mRNA vaccines on choroidal and retinal vascular system using enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography angiography (OCTA).
In this prospective cross-sectional study, 63 healthy participants (29 with Pfizer-BioNTech, 34 with Sinovac-CoronaVac) were evaluated after the first dose of vaccination. Vessel density (VD) of the superficial (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) were measured with OCTA. Choroidal thickness (CT) were measured with EDI-OCT. Measurements were performed at the 2 week and the 4 week after vaccinations and compared to pre-vaccination values.
Regarding Pfizer-BioNTech vaccination, CT in the subfoveal and nasal region significantly increased between the pre-vaccination and post-vaccination 2 week and then significantly decreased to pre-vaccine values at 4 week. The SCP-VD (whole image, fovea, parafovea, perifovea temporal) variables showed a significant decrease at 2 week. The DCP-VD inferior hemi, parafovea inferior hemi, parafovea inferior variables demonstrated a significant decrease at 2 week. The perifovea DCP-VD variables also showed a significant decrease at 2 week, and these variables returned to pre-vaccination values after 4 weeks. The CC-VD variables showed a significant decrease between pre-vaccine and 2 week post-vaccination. Regarding the Sinovac-CoronaVac vaccination, there was no statistically significant difference in CT and VD values before and after vaccination (p> 0.05).
Our study showed significant alterations in retinal vascular density and CT for the Pfizer-BioNTech vaccine at the 2 week, and these parameters became compatible with pre-vaccination values at the 4 week. In contrast, no differences were observed after the Sinovac-Coronovac vaccination.
使用增强深度成像光学相干断层扫描（EDI-OCT）和光相干断层扫描血管造影（OCTA）评估科兴新冠疫苗和辉瑞 mRNA 疫苗对脉络膜和视网膜血管系统的影响。
在这项前瞻性的横断面研究中，对 63 名健康参与者（29 名接受辉瑞-BioNTech 疫苗，34 名接受科兴新冠疫苗）进行了评估，这些参与者在接种第一剂疫苗后进行了评估。OCTA 测量了浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）和脉络膜毛细血管（CC）的血管密度（VD）。EDI-OCT 测量了脉络膜厚度（CT）。在接种疫苗后 2 周和 4 周进行测量，并与接种前的值进行比较。
在辉瑞-BioNTech 疫苗接种方面，亚黄斑区和鼻侧 CT 在接种前与接种后 2 周显著增加，然后在 4 周时显著降低至接种前水平。整个图像、黄斑、旁黄斑和周边黄斑的 SCP-VD（全像、黄斑、旁黄斑、周边黄斑）变量在 2 周时显著降低。DCP-VD 下半球、下旁黄斑、下旁黄斑变量在 2 周时显著降低。周边 DCP-VD 变量也在 2 周时显著降低，这些变量在 4 周后恢复到接种前水平。CC-VD 变量在接种前和 2 周后显著降低。在科兴新冠疫苗接种方面，CT 和 VD 值在接种前后无统计学差异（p>0.05）。
我们的研究显示，辉瑞-BioNTech 疫苗在接种后 2 周时视网膜血管密度和 CT 出现显著变化，这些参数在接种后 4 周时与接种前值相匹配。相比之下，接种科兴新冠疫苗后没有观察到差异。
