Umraniye Training and Research Hospital, Department of Obstetrics and Gynecology - İstanbul, Turkey.
Umraniye Training and Research Hospital, Department of Obstetrics and Gynecology, Maternal Fetal Unit - İstanbul, Turkey.
Rev Assoc Med Bras (1992). 2024 Oct 7;70(10):e20240660. doi: 10.1590/1806-9282.20240660. eCollection 2024.
The objective of this study was to investigate serum Metrnl levels in pregnant women with gestational diabetes mellitus and compare them with pregnant women without gestational diabetes mellitus.
The gestational diabetes mellitus group consisted of 87 pregnant women diagnosed with gestational diabetes mellitus, and the control group consisted of 93 healthy pregnant women without gestational diabetes mellitus. Serum Metrnl levels were determined by the enzyme-linked immunosorbent assay method.
The two groups were similar in terms of demographic features. The median serum Metrnl level was found to be 1.16 ng/mL in the gestational diabetes mellitus group, while it was determined as 2.2 ng/mL in the control group (p=0.001). The two groups were divided into two subgroups based on participants' body mass index, normal weight and overweight. The lowest median Metrnl level was detected in the normal weight gestational diabetes mellitus group, followed by the overweight gestational diabetes mellitus group, normal weight control group, and overweight control group (1.1, 1.2, 2, and 2.4 ng/mL, respectively). Receiver operating curve analysis was performed to determine the value of the serum Metrnl level in terms of predicting gestational diabetes mellitus. The area under the curve analysis of serum Metrnl for gestational diabetes mellitus estimation was 0.768 (p=0.000, 95%CI 0.698-0.839). The optimal cutoff value for serum Metrnl level was determined as 1.53 ng/mL with 69% sensitivity and 70% specificity.
Serum Metrnl levels in pregnant women with gestational diabetes mellitus were found to be significantly lower than in pregnant women without gestational diabetes mellitus. The mechanisms underlying the decrease in serum Metrnl levels in gestational diabetes mellitus remain unclear for now, and future studies will reveal the role of Metrnl in the pathophysiology of gestational diabetes mellitus.
本研究旨在探讨妊娠期糖尿病孕妇血清 Metrnl 水平，并与非妊娠期糖尿病孕妇进行比较。
将 87 例妊娠期糖尿病孕妇纳入妊娠期糖尿病组，93 例非妊娠期糖尿病孕妇纳入对照组。采用酶联免疫吸附法测定血清 Metrnl 水平。
两组患者的一般特征无统计学差异。妊娠期糖尿病组血清 Metrnl 中位数为 1.16ng/ml，对照组为 2.2ng/ml（p=0.001）。根据患者的 BMI 将两组分为正常体重组和超重组。正常体重妊娠期糖尿病组血清 Metrnl 中位数最低，其次为超重妊娠期糖尿病组、正常体重对照组和超重对照组（分别为 1.1、1.2、2 和 2.4ng/ml）。进行受试者工作特征曲线分析，以评估血清 Metrnl 水平预测妊娠期糖尿病的价值。曲线下面积分析显示，血清 Metrnl 预测妊娠期糖尿病的曲线下面积为 0.768（p=0.000，95%CI 0.698-0.839）。血清 Metrnl 水平的最佳截断值为 1.53ng/ml，其敏感性为 69%，特异性为 70%。
妊娠期糖尿病孕妇血清 Metrnl 水平显著低于非妊娠期糖尿病孕妇。目前尚不清楚血清 Metrnl 水平降低的机制，未来的研究将揭示 Metrnl 在妊娠期糖尿病发病机制中的作用。
