Department of Obstetrics and Gynecology, Nigde Omer Halis Demir Research and Education Hospital, Nigde, Turkiye.
Medical Student, School of Medicine, Gazi University, Ankara, Turkiye.
Biotech Histochem. 2023 May;98(4):243-254. doi: 10.1080/10520295.2023.2176546. Epub 2023 Feb 24.
We investigated the presence of asprosin (ASP), betatrophin, elabela (ELA), glucagon and subfatin (SUB) in the milk of mothers with gestational diabetes mellitus (GDM) and compared their levels with blood levels. We also investigated whether these peptides are synthesized by the breast. We investigated 12 volunteer mothers with GDM and 14 pregnant non-GDM control mothers. The peptides were measured using ELISA and their tissue localization was determined using immunohistochemistry. Breast milk contains ASP, betatrophin, ELA, glucagon and SUB. The amount of the peptides ranged from highest to the lowest in colostrum, transitional milk and mature milk. The amount of peptides in the milk was greater than for blood. The peptides, except for ELA, were increased in milk and blood by GDM. Betatrophin and ELA are synthesized in the connective tissue of the breast. ASP, glucagon and SUB are synthesized in the alveolar tissue of the breast. These peptides in breast milk may contribute to the development of the gastrointestinal tract of newborns and infants.
我们研究了妊娠期糖尿病（GDM）母亲乳汁中天门冬氨酸蛋白（ASP）、betatrophin、elabela（ELA）、胰高血糖素和 subfatin（SUB）的存在情况，并将其水平与血液水平进行了比较。我们还研究了这些肽是否由乳腺合成。我们研究了 12 名志愿的 GDM 母亲和 14 名妊娠非 GDM 对照母亲。使用 ELISA 测量了这些肽，并用免疫组织化学确定了它们的组织定位。母乳中含有 ASP、betatrophin、ELA、胰高血糖素和 SUB。这些肽在初乳、过渡乳和成熟乳中的含量从最高到最低。肽在乳汁中的含量大于血液中的含量。除 ELA 外，GDM 使乳汁和血液中的肽增加。betatrophin 和 ELA 在乳腺的结缔组织中合成。ASP、胰高血糖素和 SUB 在乳腺的肺泡组织中合成。这些在母乳中的肽可能有助于新生儿和婴儿胃肠道的发育。
