University of Health Sciences, Turkish Ministry of Health, İstanbul Training and Research Hospital, Department of General Surgery - İstanbul, Turkey.
University of Health Sciences, Turkish Ministry of Health, İstanbul Training and Research Hospital, Department of Medical Pathology - İstanbul, Turkey.
Rev Assoc Med Bras (1992). 2024 Oct 7;70(10):e20240833. doi: 10.1590/1806-9282.20240833. eCollection 2024.
Phyllodes tumors in the breast are exceptionally uncommon fibroepithelial tumors. In the literature, they are typically categorized as benign phyllodes tumor, borderline phyllodes tumor, and malignant phyllodes tumor. This study aims to assess and present the clinical and surgical outcomes of patients diagnosed with phyllodes tumor.
The outcomes of patients aged 18 years and above diagnosed with phyllodes tumor between 2006 and 2023 were retrospectively reviewed. Patients were grouped as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared by clinical and surgical results.
Of all 57 patients with phyllodes tumor, 64.9% (n=37) were benign phyllodes tumor and 35.1% (n=20) were borderline/malignant phyllodes tumor [22.8% (n=13) borderline phyllodes tumor and 12.3% (n=7) malignant phyllodes tumor]. When the patients were divided into two groups as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared, our cumulative (total) recurrence rate was 14.0%, with final surgical margin width between groups [(0<final surgical margin<2 mm vs final surgical margin≥2 mm) (p=0.154)] and recurrence [(8.1% benign phyllodes tumor vs 25.0% borderline/malignant phyllodes tumor) (p=0.080)]; there was no significant difference between our rates.
Phyllodes tumors of the breast can be followed up with a narrow negative surgical margin (0 mm<final surgical margin<2 mm). However, after the initial surgery, re-excision is recommended for positive margins, while a wider surgical margin (≥10 mm) is not necessary for excision.
乳腺叶状肿瘤是一种非常罕见的纤维上皮性肿瘤。在文献中，它们通常被分为良性叶状肿瘤、交界性/恶性叶状肿瘤。本研究旨在评估和呈现诊断为叶状肿瘤患者的临床和手术结果。
回顾性分析了 2006 年至 2023 年间诊断为叶状肿瘤的年龄在 18 岁及以上的患者的结果。根据临床和手术结果，将患者分为良性叶状肿瘤和交界性/恶性叶状肿瘤组进行比较。
在所有 57 例叶状肿瘤患者中，64.9%（n=37）为良性叶状肿瘤，35.1%（n=20）为交界性/恶性叶状肿瘤[22.8%（n=13）交界性叶状肿瘤和 12.3%（n=7）恶性叶状肿瘤]。当患者分为良性叶状肿瘤和交界性/恶性叶状肿瘤两组进行比较时，我们的累积（总）复发率为 14.0%，两组间的最终手术切缘宽度[（0<最终手术切缘<2mm 与最终手术切缘≥2mm）（p=0.154）]和复发[（8.1%良性叶状肿瘤与 25.0%交界性/恶性叶状肿瘤）（p=0.080）]差异无统计学意义。
乳腺叶状肿瘤可以通过窄的阴性手术切缘（0mm<最终手术切缘<2mm）进行随访。然而，在初次手术后，对于阳性切缘建议再次切除，而不需要广泛的手术切缘（≥10mm）。
