Coppi F, Ruoppolo M, Mandressi A, Bellorofonte C, Gonnella G, Trinchieri A
Chemioterapia. 1985 Dec;4(6):467-70.
We studied the effect of oral Bacillus subtilis spore administration in a group of 95 patients with stones-associated recurrent urinary tract infections. There was a significant reduction in the frequency of infection episodes in the group treated with Bacillus subtilis spores plus antibiotics (treated group) compared with the group treated with antibiotics alone (controls). Urinary pH decreased significantly in the treated group compared with the controls. Patients with stone disease in situ had a worse prognosis. The immunomodulatory and stabilizing effect of Bacillus subtilis spores on the intestinal flora is probably responsible for this improvement.
我们研究了口服枯草芽孢杆菌孢子对95例伴有结石的复发性尿路感染患者的影响。与仅接受抗生素治疗的组（对照组）相比，接受枯草芽孢杆菌孢子加抗生素治疗的组（治疗组）感染发作频率显著降低。与对照组相比，治疗组的尿液pH值显著下降。原位结石病患者的预后较差。枯草芽孢杆菌孢子对肠道菌群的免疫调节和稳定作用可能是导致这种改善的原因。
