International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
EBioMedicine. 2024 Nov;109:105381. doi: 10.1016/j.ebiom.2024.105381. Epub 2024 Oct 8.
Despite promising basic science discoveries and a surge in clinical trials, the quest for effective treatments that restore neurological function after spinal cord injury lags on. While "failed" in a conventional sense, emerging solutions to longstanding challenges represent promising steps towards a future with effective interventions. In this personal view, we highlight clinical trials implementing new solutions and their impact on the field. Our perspective is that, ultimately, the integration of shared knowledge, adaptive designs, and a deeper understanding of the intricacies of spinal cord injury holds promise of unlocking of major breakthroughs, leading to improved outcomes for people with spinal cord injury.
尽管基础科学发现令人振奋，临床试验也层出不穷，但在脊髓损伤后恢复神经功能的有效治疗方法的研究仍进展缓慢。虽然从传统意义上讲这些研究“失败”了，但这些长期挑战的新兴解决方案代表着迈向有效干预未来的有希望的步骤。在这篇个人观点中，我们强调了实施新解决方案的临床试验及其对该领域的影响。我们的观点是，最终，共享知识的整合、适应性设计以及对脊髓损伤复杂性的更深入理解，有望实现重大突破，为脊髓损伤患者带来更好的结果。
