CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China; Neuroscience and Behaviour Laboratory, Italian Institute of Technology, Rome 00161, Italy.
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Cell Rep Med. 2024 Oct 15;5(10):101784. doi: 10.1016/j.xcrm.2024.101784. Epub 2024 Oct 8.
Identifying neural biomarkers of pain has long been a central theme in pain neuroscience. Here, we review the state-of-the-art candidates for neural biomarkers of acute and chronic pain. We classify these potential neural biomarkers into five categories based on the nature of their target variables, including neural biomarkers of (1) within-individual perception, (2) between-individual sensitivity, and (3) discriminability for acute pain, as well as (4) assessment and (5) prospective neural biomarkers for chronic pain. For each category, we provide a synthesized review of candidate biomarkers developed using neuroimaging techniques including functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI), and electroencephalography (EEG). We also discuss the conceptual and practical challenges in developing neural biomarkers of pain. Addressing these challenges, optimal biomarkers of pain can be developed to deepen our understanding of how the brain represents pain and ultimately help alleviate patients' suffering and improve their well-being.
长期以来，识别疼痛的神经生物标志物一直是疼痛神经科学的核心主题。在这里，我们回顾了急性和慢性疼痛的神经生物标志物的最新候选者。我们根据目标变量的性质将这些潜在的神经生物标志物分为五类，包括用于（1）个体内感知、（2）个体间敏感性和（3）急性疼痛的可辨别性的神经生物标志物，以及（4）评估和（5）慢性疼痛的前瞻性神经生物标志物。对于每种类别，我们提供了使用神经影像学技术（包括功能磁共振成像 (fMRI)、结构磁共振成像 (sMRI) 和脑电图 (EEG)）开发的候选生物标志物的综合综述。我们还讨论了开发疼痛神经生物标志物的概念和实际挑战。解决这些挑战，可以开发出最佳的疼痛生物标志物，以加深我们对大脑如何表示疼痛的理解，并最终帮助减轻患者的痛苦，提高他们的幸福感。
