DeForge Teagan L, Momen Mehdi, Conidi Gabi, Muir Peter, Sample Susannah J
J Am Vet Med Assoc. 2024 Oct 9;263(3):318-322. doi: 10.2460/javma.24.06.0406. Print 2025 Mar 1.
Cruciate ligament rupture (CR) in Labrador Retrievers is a complex polygenic disease with high heritability. The environmental contribution to CR risk remains poorly characterized. An accurate genetic risk test for CR in the Labrador Retriever has been developed. This enables evaluation of environmental risk with knowledge of genetic disease predisposition through study of dogs with phenotypic disease status that is discordant with their genetic risk. The objective of this study was to identify environmental factors that contribute to CR in Labrador Retrievers through evaluation of dogs with clinical phenotypes that are discordantly predicted with the use of genetic markers.
Dogs were prospectively recruited between January 2013 and December 2022. To study discordant subjects, case dogs with a posterior risk probability value < 0.75 and control dogs with a posterior risk probability of > 0.25, determined with the use of an average of 8 statistical models, were selected. The environmental factors investigated were neuter status, age of neuter, withers height measured at the dorsal-most ridge between the scapulae, weight, body mass index, and athletic activity.
Ninety three dogs were discordant: 58 dogs were discordant CR cases, and 35 dogs were discordant CR controls. Neutering before 12 months of age was a significant risk factor for CR development. Sex, neuter status, or status as an athlete was not associated with CR risk.
Neutering before 12 months of age influences risk of CR in Labrador Retrievers.
This information can inform management decisions about Labrador Retrievers regarding age of neutering, body condition, and athletic activity. The primary factor influencing CR development in Labrador Retrievers is polygenic intrinsic genetic risk.
拉布拉多寻回犬的十字韧带破裂（CR）是一种具有高遗传性的复杂多基因疾病。环境因素对CR风险的影响仍未得到充分描述。已开发出一种针对拉布拉多寻回犬CR的精确遗传风险检测方法。通过研究表型疾病状态与其遗传风险不一致的犬只，这使得在了解遗传疾病易感性的情况下评估环境风险成为可能。本研究的目的是通过评估临床表型与使用基因标记预测结果不一致的犬只，来确定导致拉布拉多寻回犬CR的环境因素。
在2013年1月至2022年12月期间前瞻性招募犬只。为了研究不一致的个体，选择使用平均8种统计模型确定的后验风险概率值<0.75的病例犬和后验风险概率>0.25的对照犬。所研究的环境因素包括去势状态、去势年龄、在肩胛之间最背侧嵴处测量的肩高、体重、体重指数和运动活动。
93只犬只表现不一致：58只为CR病例不一致，35只为CR对照不一致。12月龄前去势是CR发生的一个显著风险因素。性别、去势状态或是否为运动犬与CR风险无关。
12月龄前去势会影响拉布拉多寻回犬CR的风险。
该信息可为拉布拉多寻回犬的去势年龄、身体状况和运动活动等管理决策提供参考。影响拉布拉多寻回犬CR发生的主要因素是多基因内在遗传风险。
