Zhang Tian Hong, Chen Xing, Wei Yan Yan, Tang Xiao Chen, Xu Li Hua, Cui Hui Ru, Liu Hai Chun, Wang Zi Xuan, Chen Tao, Li Chun Bo, Wang Ji Jun
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China.
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China; Department of Psychiatry, Nantong Fourth People's Hospital and Nantong Brain Hospital, NanTong, Jiangsu, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111166. doi: 10.1016/j.pnpbp.2024.111166. Epub 2024 Oct 9.
To explore the intricate interplay among cytokines, cognitive functioning, and conversion to psychosis in individuals at clinical high-risk (CHR) for psychosis.
We initially enrolled 385 individuals at CHR and 95 healthy controls (HCs). Subsequently, 102 participants at CHR completed the 1-year follow-up assessments, and 47 participants transitioned to psychosis. We assessed the levels of interleukins (IL-1β, IL-2, IL-6, IL-8, IL-10), tumor necrosis factor-α (TNF-α), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF). We comprehensively evaluated cognitive performance across six domains, including speed of processing (SP), attention/vigilance (AV), working memory (WM), verbal learning (VeL), visual learning (ViL), and reasoning and problem-solving (RPS).
Higher baseline cognitive domain scores were associated with elevated GM-CSF and reduced VEGF levels. In the follow-up analysis, significant time effects were observed for IL-1β and IL-2. We also observed significant interaction effects between specific cognitive domains (AV, WM, VeL, and OCS) and levels of cytokine (GM-CSF, IL-1β, IL-6, and TNF-α). Changes in WM were negatively correlated with changes in TNF-α levels and positively correlated with changes in VEGF levels. Variations in VeL were inversely correlated with changes in GM-CSF and IL-10 levels, whereas changes in RPS were positively associated with changes in GM-CSF and IL-8 levels.
Our results revealed intricate associations among cytokine levels, cognitive performance, and psychosis progression.
探讨临床高危（CHR）精神病个体中细胞因子、认知功能和向精神病转化之间的复杂相互作用。
我们最初招募了385名CHR个体和95名健康对照（HC）。随后，102名CHR参与者完成了1年的随访评估，47名参与者发展为精神病。我们评估了白细胞介素（IL-1β、IL-2、IL-6、IL-8、IL-10）、肿瘤坏死因子-α（TNF-α）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）和血管内皮生长因子（VEGF）的水平。我们全面评估了六个领域的认知表现，包括处理速度（SP）、注意力/警觉性（AV）、工作记忆（WM）、言语学习（VeL）、视觉学习（ViL）以及推理和解决问题（RPS）。
较高的基线认知领域得分与GM-CSF升高和VEGF水平降低相关。在随访分析中，观察到IL-1β和IL-2有显著的时间效应。我们还观察到特定认知领域（AV、WM、VeL和OCS）与细胞因子水平（GM-CSF、IL-1β、IL-6和TNF-α）之间存在显著的交互作用。WM的变化与TNF-α水平的变化呈负相关，与VEGF水平的变化呈正相关。VeL的变化与GM-CSF和IL-10水平的变化呈负相关，而RPS的变化与GM-CSF和IL-8水平的变化呈正相关。
我们的结果揭示了细胞因子水平、认知表现和精神病进展之间的复杂关联。
