Chen Feng, Jing Kai, Zhang Zhen, Liu Xia
Department of Clinical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai, China.
Department of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Obes Rev. 2025 Feb;26(2):e13848. doi: 10.1111/obr.13848. Epub 2024 Oct 9.
Obesity is a major public health concern and burden on individuals and healthcare systems. Due to the challenges and limitations of lifestyle adjustments, it is advisable to consider pharmacological treatment for people affected by obesity. However, the side effects and limited efficacy of available drugs make the obesity drug market far from sufficient. Drug repurposing involves identifying new applications for existing drugs and offers some advantages over traditional drug development approaches including lower costs and shorter development timelines. This review aims to provide an overview of drug repurposing for anti-obesity medications, including the rationale for repurposing, the challenges and approaches, and the potential drugs that are being investigated for repurposing. Through advanced computational techniques, researchers can unlock the potential of repurposed drugs to tackle the global obesity epidemic. Further research, clinical trials, and collaborative efforts are essential to fully explore and leverage the potential of drug repurposing in the fight against obesity.
肥胖是一个重大的公共卫生问题，给个人和医疗保健系统带来负担。由于生活方式调整存在挑战和局限性，对于受肥胖影响的人群，考虑药物治疗是可取的。然而，现有药物的副作用和有限疗效使得肥胖药物市场远远不够完善。药物重新利用涉及确定现有药物的新用途，与传统药物开发方法相比具有一些优势，包括成本更低和开发时间更短。本综述旨在概述抗肥胖药物的药物重新利用，包括重新利用的基本原理、挑战和方法，以及正在研究用于重新利用的潜在药物。通过先进的计算技术，研究人员可以挖掘重新利用药物应对全球肥胖流行的潜力。进一步的研究、临床试验和合作努力对于充分探索和利用药物重新利用在对抗肥胖方面的潜力至关重要。
