CYP1A1 基因多态性与环境因素相互作用对子宫内膜癌发病风险的影响。
Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer.
机构信息
Department of Oncology, the second people's hospital of Nantong, Affiliated Nantong Rehabilitation Hospital of Nantong University.
Department of Radiotherapy, Nantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University.
出版信息
Environ Health Prev Med. 2024;29:54. doi: 10.1265/ehpm.24-00007.
BACKGROUND
The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.
METHOD
Logistic regression was performed to investigate the association between the four SNPs of the CYP1A1 gene and the risk of endometrial cancer. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the gene-environmental interaction.
RESULTS
A total of 934 women with a mean age of 61.7 ± 10.5 years were selected, including 310 endometrial cancer patients and 624 normal controls. The frequency of rs4646421- T allele was higher in endometrial cancer patients than normal controls, the T allele of rs4646421 was 28.1% in endometrial cancer patients and 21.0% in normal controls (p < 0.001). Logistic regression analysis showed that the rs4646421 - T allele was associated with increased risk of endometrial cancer, OR (95% CI) were 1.52 (1.11-1.97) and 1.91 (1.35-2.52), respectively. GMDR analysis found a significant two-locus model (p = 0.0107) involving rs4646421 and abdominal obesity (defined by waist circumference), indicating a potential gene-environment interaction between rs4646421 and abdominal obesity. Abdominal obese subjects with rs4646421- CT or TT genotype have the highest risk of endometrial cancer, compared to non-abdominal obese subjects with the rs4646421- CC genotype, the OR (95%CI) was 2.23 (1.62-2.91).
CONCLUSIONS
Both the rs4646421- T allele and the interaction between rs4646421 and abdominal obesity were associated with increased risk of endometrial cancer.
背景
本研究旨在探讨细胞色素 P4501A1（CYP1A1）基因单核苷酸多态性（SNP）与基因-环境相互作用对中国女性子宫内膜癌易感性的影响。
方法
采用 logistic 回归分析 CYP1A1 基因四个 SNP 与子宫内膜癌风险的关系。采用广义多因素维度缩减法（GMDR）分析基因-环境的相互作用。
结果
共纳入 934 名年龄 61.7 ± 10.5 岁的女性，其中 310 例为子宫内膜癌患者，624 例为正常对照。子宫内膜癌患者 rs4646421-T 等位基因频率高于正常对照，rs4646421-T 等位基因在子宫内膜癌患者中的频率为 28.1%，在正常对照中的频率为 21.0%（p＜0.001）。logistic 回归分析显示，rs4646421-T 等位基因与子宫内膜癌风险增加相关，OR（95%CI）分别为 1.52（1.11-1.97）和 1.91（1.35-2.52）。GMDR 分析发现一个显著的两因素模型（p=0.0107），涉及 rs4646421 和腹型肥胖（以腰围定义），提示 rs4646421 与腹型肥胖之间存在潜在的基因-环境相互作用。与 rs4646421-CC 基因型的非腹型肥胖者相比，rs4646421-CT 或 TT 基因型的腹型肥胖者患子宫内膜癌的风险最高，OR（95%CI）为 2.23（1.62-2.91）。
结论
rs4646421-T 等位基因和 rs4646421 与腹型肥胖的相互作用均与子宫内膜癌风险增加相关。
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