Department of Cardiothoracic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China.
Department of Science and Education, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, Changzhi 046000, China.
Biosci Rep. 2020 Sep 30;40(9). doi: 10.1042/BSR20202275.
Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Two previous meta-analyses have been reported on the issue in 2011 and 2014. However, several new articles since then have been published. In addition, their meta-analyses did not valuate the credibility of significantly positive results.
We performed an updated meta-analysis to solve the controversy following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria were used to verify the credibility of meta-analyses.
Twenty-three publications including 5734 LC cases and 7066 controls met the inclusion criteria in the present study. A significantly increased risk of LC was found in overall analysis, Asians and Indians. However, all positive results were considered as 'less-credible' when we used the Venice criteria, FPRP, and BFDP test to assess the credibility of the positive results.
These positive findings should be interpreted with caution and results indicate that significant associations may be less-credible, there are no significantly increased LC risk between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms.
许多研究已经探索了谷胱甘肽-S-转移酶 M1（GSTM1）存在/缺失和细胞色素 P4501A1（CYP1A1）MspI 多态性与肺癌（LC）风险的联合效应，但结果存在矛盾。2011 年和 2014 年已经有两项关于这个问题的荟萃分析报告。然而，此后又发表了一些新的文章。此外，他们的荟萃分析没有评估显著阳性结果的可信度。
我们根据系统评价和荟萃分析的首选报告项目指南进行了更新的荟萃分析，以解决争议。
虚假阳性报告概率（FPRP）、贝叶斯虚假发现概率（BFDP）和威尼斯标准用于验证荟萃分析的可信度。
本研究共纳入 23 项出版物，包括 5734 例 LC 病例和 7066 例对照。总体分析、亚洲人和印度人发现 LC 风险显著增加。然而，当我们使用威尼斯标准、FPRP 和 BFDP 测试来评估阳性结果的可信度时，所有阳性结果都被认为是“可信度较低”。
这些阳性发现应谨慎解释，结果表明，联合效应的 GSTM1 存在/缺失和 CYP1A1 MspI 多态性之间可能没有显著增加的 LC 风险。
