• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Onyx 可防止介入栓塞治疗期间破裂的动脉瘤出血。

Onyx prevents the bleeding of ruptured aneurysms during interventional embolization.

机构信息

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.

出版信息

Neurosurg Rev. 2024 Oct 10;47(1):770. doi: 10.1007/s10143-024-02953-5.

DOI:10.1007/s10143-024-02953-5
PMID:39384599
Abstract

Endovascular treatment has been acknowledged as an effective treatment for intracranial aneurysms, showcasing favorable clinical outcomes and providing robust protection against rebleeding and rupture. Notably, during the endovascular procedure, significant complications include intraprocedural aneurysmal rupture (IAR) induced by microcatheters, microguidewires, or spring coils, along with thromboembolic events, significantly escalating patient mortality and disability. Current approaches against for IARs involve various strategies such as heparin reversal, compression of the common carotid artery or upstream soft guidewire to mitigate blood flow, management of intracranial pressure and blood pressure, and balloon-assisted or unassisted rapid dense embolization of the aneurysm. Nevertheless, these measures may prove insufficient in halting hemorrhage, especially in scenarios where additional coils cannot be added for dense embolization due to inherent limitations. In this context, we introduce a novel strategy for the prompt, safe, and effective cessation of aneurysm bleeding, which involves injecting an appropriate quantity of Onyx into the aneurysm through a microcatheter while safeguarded by an aneurysm-carrying arterial braided stent. Initially, we attempted dense embolization by filling multiple coils. However, in cases where continued coil filling proved unfeasible or failed to sufficiently prevent contrast agent extravasation, we opted for Onyx injection into the aneurysm. Utilizing Onyx effectively prevented further blood extravasation without adversely impacting the aneurysm-carrying artery or distal vessels, leading to favorable prognoses for all patients. This article delineates our embolization strategy, highlighting the efficacy and safety of Onyx injection as an alternative or complementary measure in managing complications arising from endovascular coil embolization.

摘要

血管内治疗已被公认为治疗颅内动脉瘤的有效方法,具有良好的临床效果,并能强有力地防止再出血和破裂。值得注意的是,在血管内治疗过程中,微导管、微导丝或弹簧圈引起的术中动脉瘤破裂(IAR)以及血栓栓塞事件是显著的并发症,显著增加了患者的死亡率和残疾率。目前针对 IAR 的方法包括肝素逆转、压迫颈总动脉或上游软导丝以减轻血流、颅内压和血压管理,以及球囊辅助或非辅助快速致密栓塞动脉瘤等各种策略。然而,这些措施可能不足以停止出血,尤其是在由于固有限制而无法添加更多线圈进行致密栓塞的情况下。在这种情况下,我们提出了一种新的策略,通过在带有动脉瘤的动脉编织支架的保护下,通过微导管向动脉瘤中注射适量的 Onyx,以快速、安全、有效地停止动脉瘤出血。首先,我们试图通过填充多个线圈进行致密栓塞。然而,在继续填充线圈不可行或无法充分防止造影剂外渗的情况下,我们选择向动脉瘤中注射 Onyx。有效地使用 Onyx 防止了进一步的血液外渗,而不会对携带动脉瘤的动脉或远端血管产生不利影响,所有患者的预后均良好。本文描述了我们的栓塞策略,强调了 Onyx 注射作为血管内线圈栓塞治疗并发症的替代或补充措施的疗效和安全性。

相似文献

1
Onyx prevents the bleeding of ruptured aneurysms during interventional embolization.Onyx 可防止介入栓塞治疗期间破裂的动脉瘤出血。
Neurosurg Rev. 2024 Oct 10;47(1):770. doi: 10.1007/s10143-024-02953-5.
2
Intrasaccular combination of metallic coils and onyx liquid embolic agent for the endovascular treatment of cerebral aneurysms.血管内治疗脑动脉瘤时金属弹簧圈与Onyx液体栓塞剂的囊内联合应用
J Neurosurg. 2006 Nov;105(5):706-12. doi: 10.3171/jns.2006.105.5.706.
3
Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate.新生儿小脑下前动脉破裂的Onyx栓塞术
Childs Nerv Syst. 2019 Feb;35(2):373-378. doi: 10.1007/s00381-018-3968-6. Epub 2018 Sep 10.
4
Onyx embolization of a ruptured aneurysm in a patient with moyamoya disease.烟雾病患者破裂动脉瘤的Onyx栓塞术。
J Clin Neurosci. 2015 Oct;22(10):1693-6. doi: 10.1016/j.jocn.2015.05.017. Epub 2015 Jul 22.
5
In vivo intraaneurysmal pressure measurements in experimental lateral wall aneurysms before and after onyx embolization.实验性侧壁动脉瘤在使用Onyx栓塞前后的体内动脉瘤内压力测量。
Surg Neurol. 2006 Sep;66(3):252-6; discussion 257. doi: 10.1016/j.surneu.2006.03.036.
6
Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms.小脑后下动脉远端夹层动脉瘤的Onyx栓塞术
J Neurointerv Surg. 2016 May;8(5):501-6. doi: 10.1136/neurintsurg-2014-011622. Epub 2015 Apr 2.
7
Outcomes of Onyx® Embolization of Type II Endoleaks After Endovascular Repair of Abdominal Aortic Aneurysms.腹主动脉瘤血管内修复术后Ⅱ型内漏的Onyx®栓塞治疗效果
Ann Vasc Surg. 2020 Aug;67:223-231. doi: 10.1016/j.avsg.2020.02.013. Epub 2020 Mar 13.
8
Application of endovascular coiling and subsequent Onyx 34 embolization in anterior communicating artery aneurysms with adjacent hematoma.血管内栓塞术及随后的Onyx 34栓塞术在前交通动脉瘤合并相邻血肿中的应用。
Clin Neurol Neurosurg. 2014 Aug;123:40-4. doi: 10.1016/j.clineuro.2014.05.007. Epub 2014 May 14.
9
Endovascular treatment of distal intracranial aneurysms with Onyx 18/34.使用Onyx 18/34对颅内远端动脉瘤进行血管内治疗。
Clin Neurol Neurosurg. 2013 Dec;115(12):2528-32. doi: 10.1016/j.clineuro.2013.10.018. Epub 2013 Nov 1.
10
Parent artery occlusion with Onyx for distal aneurysms of posterior inferior cerebellar artery: a single-centre experience in a series of 15 patients.用 Onyx 闭塞载瘤动脉治疗小脑后下动脉远端动脉瘤:15 例患者的单中心经验。
Neurol India. 2013 May-Jun;61(3):265-9. doi: 10.4103/0028-3886.115066.

引用本文的文献

1
Unexpected ocular morbidity after middle meningeal artery embolization: Lessons learned from a case of anastomotic-related diplopia.脑膜中动脉栓塞术后意外的眼部并发症:一例与吻合相关的复视病例的经验教训
World J Clin Cases. 2025 Oct 6;13(28):109679. doi: 10.12998/wjcc.v13.i28.109679.

本文引用的文献

1
Risk Factors for Recanalization after Coil Embolization.弹簧圈栓塞术后再通的危险因素
J Pers Med. 2021 Aug 14;11(8):793. doi: 10.3390/jpm11080793.
2
Porous Media Computational Fluid Dynamics and the Role of the First Coil in the Embolization of Ruptured Intracranial Aneurysms.多孔介质计算流体动力学及首个弹簧圈在破裂颅内动脉瘤栓塞中的作用
J Clin Med. 2021 Mar 24;10(7):1348. doi: 10.3390/jcm10071348.
3
Successfully disposal of an acute MCA occlusion by Onyx during AVM embolism.Onyx 在 AVM 栓塞期间成功处理了急性 MCA 闭塞。
Br J Neurosurg. 2020 Dec;34(6):628-631. doi: 10.1080/02688697.2019.1661963. Epub 2019 Sep 13.
4
Computational fluid dynamics (CFD) using porous media modeling predicts recurrence after coiling of cerebral aneurysms.使用多孔介质模型的计算流体动力学(CFD)可预测脑动脉瘤栓塞术后的复发情况。
PLoS One. 2017 Dec 28;12(12):e0190222. doi: 10.1371/journal.pone.0190222. eCollection 2017.
5
Finite element modeling of endovascular coiling and flow diversion enables hemodynamic prediction of complex treatment strategies for intracranial aneurysm.颅内动脉瘤血管内栓塞和血流导向的有限元建模能够对复杂治疗策略进行血流动力学预测。
J Biomech. 2015 Sep 18;48(12):3332-40. doi: 10.1016/j.jbiomech.2015.06.018. Epub 2015 Jun 27.
6
Morphological predictors of intraprocedural rupture during coil embolization of ruptured cerebral aneurysms: do small basal outpouchings carry higher risk?破裂性脑动脉瘤弹簧圈栓塞术中瘤内破裂的形态学预测因素:小基底袋状突出是否具有更高风险?
J Neurosurg. 2014 Sep;121(3):605-12. doi: 10.3171/2014.5.JNS132107. Epub 2014 Jun 27.
7
Endovascular treatment of anterior communicating artery aneurysms: a systematic review and meta-analysis.前交通动脉瘤的血管内治疗:一项系统评价和荟萃分析。
AJNR Am J Neuroradiol. 2014 May;35(5):943-7. doi: 10.3174/ajnr.A3802. Epub 2013 Nov 28.
8
Is heparin reversal required for the safe performance of percutaneous endovascular aortic aneurysm repair?经皮血管内主动脉瘤修复术安全实施是否需要肝素逆转?
Ann Vasc Surg. 2013 Nov;27(8):1049-53. doi: 10.1016/j.avsg.2013.04.008. Epub 2013 Sep 5.
9
Multicenter registry of liquid embolic treatment of cerebral aneurysms.脑动脉瘤液体栓塞治疗的多中心注册研究
World Neurosurg. 2014 Dec;82(6):e731-8. doi: 10.1016/j.wneu.2013.03.070. Epub 2013 Mar 30.
10
Interdisciplinary treatment of unruptured intracranial aneurysms: impact of intraprocedural rupture and ischemia in 563 aneurysms.未破裂颅内动脉瘤的多学科治疗:563 个动脉瘤中术中破裂和缺血的影响。
J Neurol. 2013 May;260(5):1304-13. doi: 10.1007/s00415-012-6795-9. Epub 2012 Dec 23.