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Onyx 可防止介入栓塞治疗期间破裂的动脉瘤出血。

Onyx prevents the bleeding of ruptured aneurysms during interventional embolization.

机构信息

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.

出版信息

Neurosurg Rev. 2024 Oct 10;47(1):770. doi: 10.1007/s10143-024-02953-5.

Abstract

Endovascular treatment has been acknowledged as an effective treatment for intracranial aneurysms, showcasing favorable clinical outcomes and providing robust protection against rebleeding and rupture. Notably, during the endovascular procedure, significant complications include intraprocedural aneurysmal rupture (IAR) induced by microcatheters, microguidewires, or spring coils, along with thromboembolic events, significantly escalating patient mortality and disability. Current approaches against for IARs involve various strategies such as heparin reversal, compression of the common carotid artery or upstream soft guidewire to mitigate blood flow, management of intracranial pressure and blood pressure, and balloon-assisted or unassisted rapid dense embolization of the aneurysm. Nevertheless, these measures may prove insufficient in halting hemorrhage, especially in scenarios where additional coils cannot be added for dense embolization due to inherent limitations. In this context, we introduce a novel strategy for the prompt, safe, and effective cessation of aneurysm bleeding, which involves injecting an appropriate quantity of Onyx into the aneurysm through a microcatheter while safeguarded by an aneurysm-carrying arterial braided stent. Initially, we attempted dense embolization by filling multiple coils. However, in cases where continued coil filling proved unfeasible or failed to sufficiently prevent contrast agent extravasation, we opted for Onyx injection into the aneurysm. Utilizing Onyx effectively prevented further blood extravasation without adversely impacting the aneurysm-carrying artery or distal vessels, leading to favorable prognoses for all patients. This article delineates our embolization strategy, highlighting the efficacy and safety of Onyx injection as an alternative or complementary measure in managing complications arising from endovascular coil embolization.

摘要

血管内治疗已被公认为治疗颅内动脉瘤的有效方法,具有良好的临床效果,并能强有力地防止再出血和破裂。值得注意的是,在血管内治疗过程中,微导管、微导丝或弹簧圈引起的术中动脉瘤破裂(IAR)以及血栓栓塞事件是显著的并发症,显著增加了患者的死亡率和残疾率。目前针对 IAR 的方法包括肝素逆转、压迫颈总动脉或上游软导丝以减轻血流、颅内压和血压管理,以及球囊辅助或非辅助快速致密栓塞动脉瘤等各种策略。然而,这些措施可能不足以停止出血,尤其是在由于固有限制而无法添加更多线圈进行致密栓塞的情况下。在这种情况下,我们提出了一种新的策略,通过在带有动脉瘤的动脉编织支架的保护下,通过微导管向动脉瘤中注射适量的 Onyx,以快速、安全、有效地停止动脉瘤出血。首先,我们试图通过填充多个线圈进行致密栓塞。然而,在继续填充线圈不可行或无法充分防止造影剂外渗的情况下,我们选择向动脉瘤中注射 Onyx。有效地使用 Onyx 防止了进一步的血液外渗,而不会对携带动脉瘤的动脉或远端血管产生不利影响,所有患者的预后均良好。本文描述了我们的栓塞策略,强调了 Onyx 注射作为血管内线圈栓塞治疗并发症的替代或补充措施的疗效和安全性。

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