Ito Kazuyo, Hoerig Cameron, Dan Yee Shan, McFadden Sally A, Mamou Jonathan, Hoang Quan V
Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore, Singapore.
Division of Advanced Applied Physics, Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Commun Eng. 2024 Oct 9;3(1):139. doi: 10.1038/s44172-024-00280-7.
Retina-derived growth signals relayed from the choroid to the sclera cause remodeling of the extracellular scleral matrix, resulting in myopic ocular elongation. However, to the best of our knowledge, no studies have assessed changes in choroidal stromal biomechanical properties during myopia progression. Here we utilized 7 µm-resolution scanning acoustic microscopy (SAM) to assess biomechanical properties (bulk modulus (K) and mass density (rho)) of choroidal stroma from guinea pig eyes with form-deprivation (FD) induced myopia. The choroidal stroma had considerable intrinsic strength arising from its biomechanical properties and these were differentially affected by myopia in central and peripheral regions. Choroidal stromal biomechanical values were also highly correlated with those in adjacent scleral regions, and the choroidal stromal-scleral association was stronger in myopic eyes. Biomechanical changes observed in the choroidal stroma of myopic eyes were mirrored to those observed in the adjacent sclera. These findings suggest that choroidal stromal remodeling may accompany myopia and open the door to the source of the signals that cause scleral remodeling in myopia.
从脉络膜传递至巩膜的视网膜衍生生长信号会导致巩膜细胞外基质重塑，进而引起近视性眼轴延长。然而，据我们所知，尚无研究评估近视进展过程中脉络膜基质生物力学特性的变化。在此，我们利用7微米分辨率的扫描声学显微镜（SAM）来评估豚鼠形觉剥夺（FD）诱导性近视眼中脉络膜基质的生物力学特性（体积模量（K）和质量密度（rho））。脉络膜基质因其生物力学特性而具有相当大的固有强度，并且在中央和周边区域，这些特性受近视的影响有所不同。脉络膜基质生物力学值也与相邻巩膜区域的生物力学值高度相关，且在近视眼中脉络膜基质与巩膜的关联更强。在近视眼中脉络膜基质观察到的生物力学变化与在相邻巩膜中观察到的变化相似。这些发现表明脉络膜基质重塑可能伴随近视发生，并为近视中导致巩膜重塑的信号来源打开了研究之门。
