Matuszek M, Szreder Z, Korolkiewicz Z
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):875-82.
Thermoregulatory responses to prazosin and lysine-acetylsalicylate (LAS) were investigated in afebrile rabbits at different ambient temperatures, i.e. at 5, 21 and 28 degrees C. In cold as well as in heat prazosin significantly inhibited the metabolic rate. This effect was accompanied by falls in rectal temperatures, particularly at the ambient temperature of 5 degrees C. Increases in ear skin temperatures became visible only when this drug was used in rabbits maintained in the thermoneutral environment. On the other hand LAS in all tested conditions indicated a marked metabolic activity associated with an intensified respiratory heat loss. As a consequence, the rabbits responded with slight increases in body temperature. The possible mode of thermoregulatory activity of prazosin is being considered in confrontation with that of LAS.
在不同环境温度（即5℃、21℃和28℃）下，对无热原的家兔研究了其对哌唑嗪和赖氨酸乙酰水杨酸（LAS）的体温调节反应。在寒冷和炎热环境中，哌唑嗪均显著抑制代谢率。这种作用伴随着直肠温度下降，尤其是在5℃的环境温度下。仅当在热中性环境中饲养的家兔使用该药物时，耳部皮肤温度才会升高。另一方面，在所有测试条件下，LAS均显示出与增强的呼吸热损失相关的显著代谢活性。结果，家兔的体温略有升高。正在将哌唑嗪的体温调节活性的可能模式与LAS的模式进行对比研究。
