Lin M T
Pflugers Arch. 1978 Dec 28;378(2):181-4. doi: 10.1007/BF00584454.
The effects of intraperitoneal administration of sodium acetylsalicylate (aspirin) on thermoregulatory responses (Ta) of 15, 22 and 29 degrees C were assessed. Intraperitoneal administration of aspirin produced dose-dependent hypothermia at both 15 and 22 degrees C. The hypothermia was brought about by cutaneous vasodilation (as indicated by an increase of the tail and foot skin temperatures). However, in the heat (29 degrees C), i.p. administration of the same amount of aspirin produced no change in rectal temperature, since the thermo-regulatory responses were unaffected by aspirin application at this Ta. Thus it appears that aspirin increases heat loss and leads to hypothermia in rats.
评估了腹腔注射乙酰水杨酸钠（阿司匹林）对15、22和29摄氏度体温调节反应（Ta）的影响。腹腔注射阿司匹林在15和22摄氏度时均产生剂量依赖性体温过低。体温过低是由皮肤血管舒张引起的（如尾巴和足部皮肤温度升高所示）。然而，在高温环境（29摄氏度）下，腹腔注射相同剂量的阿司匹林对直肠温度没有影响，因为在此Ta下，体温调节反应不受阿司匹林应用的影响。因此，阿司匹林似乎会增加大鼠的散热并导致体温过低。
