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PD-1/PD-L1 在尿路肿瘤研究中的文献计量分析。

A bibliometric analysis of research on PD-1/PD-L1 in urinary tract tumors.

机构信息

Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.

出版信息

Hum Vaccin Immunother. 2024 Dec 31;20(1):2390727. doi: 10.1080/21645515.2024.2390727. Epub 2024 Oct 10.


DOI:10.1080/21645515.2024.2390727
PMID:39385743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11469446/
Abstract

Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are key components in immune checkpoint studies across various tumors, including those in the urinary tract. The utilization of PD-1/PD-L1 inhibitors in urinary tract tumors is on the rise. This study provides a comprehensive overview of PD-1/PD-L1 research in urinary tract tumors through bibliometric analysis. A search was conducted in the Web of Science Core Collection (WoSCC) database for academic papers on PD-1/PD-L1 in urinary tract tumors published between January 1, 1999, and September 3, 2022. Tools such as VOSviewer, CiteSpace, and an online bibliometric platform, were used for an in-depth analysis covering countries, institutions, authors, journals, references, and keywords. A total of 1,711 articles on PD-1/PD-L1 in urinary tract tumors were analyzed. The United States led in article contributions, followed by China and Japan. Harvard University was the top institution in this research area. With notable conctributions from Choueiri TK, who authored 48 related articles. was the top publisher, and Topalian SL's 2012 publication in was the most cited article. Key author keywords included "immunotherapy," "PD-L1," "renal cell carcinoma," "bladder cancer," and "immune checkpoint inhibitors." Notably, research on the role of PD-1/PD-L1 in kidney and bladder cancer has garnered significant attention.

摘要

程序性细胞死亡蛋白 1(PD-1)和程序性细胞死亡配体 1(PD-L1)是包括泌尿系统肿瘤在内的各种肿瘤免疫检查点研究的关键组成部分。PD-1/PD-L1 抑制剂在泌尿系统肿瘤中的应用正在不断增加。本研究通过文献计量学分析,对泌尿系统肿瘤中 PD-1/PD-L1 的研究进行了全面概述。在 Web of Science 核心合集(WoSCC)数据库中,对 1999 年 1 月 1 日至 2022 年 9 月 3 日期间发表的关于泌尿系统肿瘤中 PD-1/PD-L1 的学术论文进行了检索。使用了 VOSviewer、CiteSpace 和在线文献计量学平台等工具,对国家、机构、作者、期刊、参考文献和关键词进行了深入分析。共分析了 1711 篇关于泌尿系统肿瘤中 PD-1/PD-L1 的文章。美国在文章贡献方面处于领先地位,其次是中国和日本。哈佛大学是该研究领域的顶尖机构。Choueiri TK 做出了显著贡献,他撰写了 48 篇相关文章。是顶级出版商,Topalian SL 2012 年在 上发表的文章是被引频次最高的文章。主要作者关键词包括“免疫疗法”、“PD-L1”、“肾细胞癌”、“膀胱癌”和“免疫检查点抑制剂”。值得注意的是,PD-1/PD-L1 在肾和膀胱癌中的作用研究引起了广泛关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/43d773c78b0f/KHVI_A_2390727_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/b5f4ddb65590/KHVI_A_2390727_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/be7eb53cdf44/KHVI_A_2390727_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/0f1ebced470d/KHVI_A_2390727_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/43cf0f401f66/KHVI_A_2390727_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/56fd53af2948/KHVI_A_2390727_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/c86a5deec367/KHVI_A_2390727_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/143888c920f4/KHVI_A_2390727_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/a99d1f3ba73c/KHVI_A_2390727_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/8a69f2943f81/KHVI_A_2390727_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/43d773c78b0f/KHVI_A_2390727_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/b5f4ddb65590/KHVI_A_2390727_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/be7eb53cdf44/KHVI_A_2390727_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/0f1ebced470d/KHVI_A_2390727_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/43cf0f401f66/KHVI_A_2390727_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/56fd53af2948/KHVI_A_2390727_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/c86a5deec367/KHVI_A_2390727_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/143888c920f4/KHVI_A_2390727_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/a99d1f3ba73c/KHVI_A_2390727_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/8a69f2943f81/KHVI_A_2390727_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd4/11469446/43d773c78b0f/KHVI_A_2390727_F0010_OC.jpg

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引用本文的文献

[1]
Global research trends in tryptophan metabolism and cancer: a bibliometric and visualization analysis (2005-2024).

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本文引用的文献

[1]
Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials.

Mol Cancer. 2023-6-8

[2]
Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer.

Clin Cancer Res. 2023-5-15

[3]
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.

Cancer Cell. 2022-9-12

[4]
Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer.

Front Immunol. 2022-3-21

[5]
Androgen receptor activity in T cells limits checkpoint blockade efficacy.

Nature. 2022-6

[6]
Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy diminishing PD-L1 and promoting CD8 T cell-mediated ferroptosis in castration-resistant prostate cancer.

Acta Pharm Sin B. 2022-2

[7]
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.

Cell. 2022-2-3

[8]
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions.

Mol Cancer. 2022-1-21

[9]
FGFR3 Destabilizes PD-L1 via NEDD4 to Control T-cell-Mediated Bladder Cancer Immune Surveillance.

Cancer Res. 2022-1-1

[10]
The Significance of PARP1 as a biomarker for Predicting the Response to PD-L1 Blockade in Patients with PBRM1-mutated Clear Cell Renal Cell Carcinoma.

Eur Urol. 2022-2

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