Li Lanying, Zhang Xinyuan, Li Qian, Zhong Wen, Zou Hua
Department of Laboratory Medicine, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Infect Drug Resist. 2024 Oct 5;17:4301-4310. doi: 10.2147/IDR.S474304. eCollection 2024.
Candida vaginitis is widely prevalent worldwide and is one of the common gynecological disorders. The aim of this study is to analyze the sensitivity of recurrent vulvovaginal (RVVC) candidiasis to antifungal drugs and its relationship with vaginal microbiota.
We Isolated and cultured Candida from RVVC patients, mass spectrometry and broth microdilution method were used to identify and determine MIC values of antifungal drugs. Clinical medical records and vaginal microbiota of RVVC patients were also collected.
The main pathogens causing RVVC are predominantly (70.26%), but in recent years, there has been an increasing proportion of (24.46%). However, only 15.70% of Candida albicans were sensitive to Voriconazole, 35.84% to Fluconazole and 25.60% to Itraconazole. No fluconazole-resistant was found. Most strains were sensitive to voriconazole (81.80%). More important MIC values of triazoles were increased in Candida species, when exposed to clotrimazole. In addition, we found that the vaginal microecology of candida vaginitis and bacterial vaginitis was significantly different.
Triazoles resistant Candida species have emerged, leading to the failure of empirical anti-infective therapy. At the same time, the vaginal microecology of candida vaginitis and bacterial vaginitis was significantly different. In addition, a new breakpoint for Candida from RVVC needs to be established.
念珠菌性阴道炎在全球广泛流行，是常见的妇科疾病之一。本研究旨在分析复发性外阴阴道念珠菌病（RVVC）对抗真菌药物的敏感性及其与阴道微生物群的关系。
我们从RVVC患者中分离培养念珠菌，采用质谱法和肉汤微量稀释法鉴定并测定抗真菌药物的MIC值。还收集了RVVC患者的临床病历和阴道微生物群。
引起RVVC的主要病原体以（70.26%）为主，但近年来，（24.46%）的比例有所增加。然而，仅15.70%的白色念珠菌对伏立康唑敏感，35.84%对氟康唑敏感，25.60%对伊曲康唑敏感。未发现耐氟康唑的（此处原文缺失相关内容）。大多数（此处原文缺失相关内容）菌株对伏立康唑敏感（81.80%）。当念珠菌属暴露于克霉唑时，三唑类药物的MIC值升高更为明显。此外，我们发现念珠菌性阴道炎和细菌性阴道炎的阴道微生态存在显著差异。
已出现对三唑类耐药的念珠菌属，导致经验性抗感染治疗失败。同时，念珠菌性阴道炎和细菌性阴道炎的阴道微生态存在显著差异。此外,需要为RVVC患者的念珠菌建立新的药敏折点。
