Jankowski Connor S R, Weichhart Thomas
Department of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria.
Immunometabolism (Cobham). 2024 Oct 8;6(4):e00048. doi: 10.1097/IN9.0000000000000048. eCollection 2024 Oct.
Hematopoietic stem cells (HSCs) are the multipotent progenitors of all immune cells. During aging, their regenerative capacity decreases for reasons that are not well understood. Recently, Song et al investigated the roles of two metabolic proteins in age-related HSC dysfunction: CD38 (a membrane-bound NADase) and the mitochondrial calcium uniporter that transports calcium into the mitochondrial matrix. They found that the interplay between these proteins is deranged in aged HSCs, contributing to their diminished renewal capacity. These findings implicate compromised nicotinamide adenine dinucleotide metabolism as underlying HSC dysfunction in aging.
造血干细胞（HSCs）是所有免疫细胞的多能祖细胞。在衰老过程中，它们的再生能力下降，原因尚不清楚。最近，宋等人研究了两种代谢蛋白在与年龄相关的造血干细胞功能障碍中的作用：CD38（一种膜结合的烟酰胺腺嘌呤二核苷酸酶）和将钙转运到线粒体基质中的线粒体钙单向转运体。他们发现，这些蛋白之间的相互作用在衰老的造血干细胞中紊乱，导致其更新能力下降。这些发现表明，烟酰胺腺嘌呤二核苷酸代谢受损是衰老过程中造血干细胞功能障碍的潜在原因。
