通过两样本孟德尔随机化分析研究胃食管反流病与高血压之间的因果关系。
Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis.
作者信息
Li Weige, Wang Qian, Li Wenjie, Liu Xiang, Li Zuobin, Dai Qi
机构信息
Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Department of Gastroenterology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
出版信息
Front Cardiovasc Med. 2024 Sep 24;11:1326348. doi: 10.3389/fcvm.2024.1326348. eCollection 2024.
OBJECTIVE
The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis.
METHODS
The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension.
RESULTS
A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044-1.071; < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032-1.07; < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome.
CONCLUSION
There is a positive causal relationship between GERD and hypertension.
目的
本研究旨在通过两样本孟德尔随机化分析探讨胃食管反流病（GERD）与高血压之间的因果关系。
方法
GERD与高血压的相关数据来自全基因组关联研究（GWAS）数据库，并采用逆方差加权（IVW）、MR-Egger和加权中位数（WM）等方法进行两样本孟德尔随机化（MR）分析，以研究GERD与高血压之间的因果关联。
结果
共筛选出16个与GERD密切相关的单核苷酸多态性（SNP），IVW分析提示GERD与高血压之间存在因果关系（OR：1.057；95%CI：1.044 - 1.071；P＜0.05）。加权中位数分析也显示出类似关系（OR：1.051，95%CI：1.032 - 1.07；P＜0.05）。此外，未观察到异质性或水平多效性，表明结果具有稳健性。
结论
GERD与高血压之间存在正向因果关系。
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