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作者信息
Dupré Mathilde, Marc Manon, Bussières Jean-François
机构信息
, candidate au D. Pharm., est assistante de recherche à l'Unité de recherche en pratique pharmaceutique, département de pharmacie, CHU Sainte-Justine, Montréal (Québec).
, B. Pharm., M. Sc., M.B.A., F.C.S.H.P., F.O.P.Q., est responsable, Unité de recherche en pratique pharmaceutique, CHU Sainte-Justine, et professeur titulaire de clinique, Faculté de pharmacie, Université de Montréal (Québec).
出版信息
Can J Hosp Pharm. 2024 Oct 9;77(4):e3588. doi: 10.4212/cjhp.3588. eCollection 2024.
BACKGROUND
The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.
OBJECTIVE
To evaluate the effectiveness of decontamination scenarios.
METHODS
This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm).
RESULTS
Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse ( = 18), 99.90% (SD 0.15%) after 2 cleanses ( = 18), and 99.95% (SD 0.06%) after 3 cleanses ( = 15).
CONCLUSION
The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.
背景
肿瘤门诊诊所椅子的扶手经常被环磷酰胺污染。
目的
评估去污方案的有效性。
方法
这是一项描述性模拟研究，针对被10μg环磷酰胺污染的硅酮织物表面进行6种去污方案的研究。测试的去污产品（季铵盐、0.5%过氧化氢、0.005%洗涤剂和0.5%次氯酸钠）用微纤维擦拭布进行涂抹。使用具有相同环磷酰胺检测和定量限（0.0006 ng/cm）的超高效液相色谱-串联质谱系统测量残留污染。
结果
在59个样本中，3个空白样本为阴性，5个样本可测量回收率（93.7%[标准差4.6%]），51个样本为实验样本。这些试剂的平均效率大于或等于99.79%。无论使用何种试剂，一次清洁后有效性为99.30%（标准差1.20%）（n = 18），两次清洁后为99.90%（标准差0.15%）（n = 18），三次清洁后为99.95%（标准差0.06%）（n = 15）。
结论
这6种去污方案是有效的。反复清洁可使去污效果略有提高。
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