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影响使用高生物利用度口服抗生素疗法治疗人工关节感染的因素。

Factors influencing the use of highly bioavailable oral antibiotic therapy for the treatment of prosthetic joint infections.

作者信息

Granger Marie-Félixe, Leis Jerome A, Hempel Amanda, Pincus Daniel, Ravi Bheeshma, Daneman Nick, Lam Philip W

机构信息

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

出版信息

Infect Control Hosp Epidemiol. 2024 Oct 10;45(11):1-4. doi: 10.1017/ice.2024.159.

DOI:10.1017/ice.2024.159
PMID:39387188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663473/
Abstract

We conducted a retrospective cohort study to identify factors influencing intravenous (IV) versus oral antibiotic therapy in first-episode prosthetic joint infections. Of the 34/78 (44%) cases treated intravenously, negative cultures (26%), concomitant infections necessitating IV antibiotics (21%), and delays in susceptibility testing (15%) were the most common reasons for IV therapy.

摘要

我们进行了一项回顾性队列研究，以确定影响首次人工关节感染时静脉注射与口服抗生素治疗的因素。在34例（占78例中的44%）接受静脉注射治疗的病例中，培养结果为阴性（26%）、伴有需要静脉注射抗生素的感染（21%）以及药敏试验延迟（15%）是静脉注射治疗最常见的原因。

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Open Forum Infect Dis. 2024 May 15;11(6):ofae280. doi: 10.1093/ofid/ofae280. eCollection 2024 Jun.
2
Early switch from intravenous to oral antibiotic treatment in bone and joint infections.早期从静脉转为口服抗生素治疗骨和关节感染。
Clin Microbiol Infect. 2023 Sep;29(9):1133-1138. doi: 10.1016/j.cmi.2023.05.008. Epub 2023 May 12.
3
Partial-Oral Antibiotic Therapy for Bone and Joint Infections in People With Recent Injection Drug Use.近期注射吸毒者骨与关节感染的部分口服抗生素治疗
Open Forum Infect Dis. 2023 Jan 7;10(1):ofad005. doi: 10.1093/ofid/ofad005. eCollection 2023 Jan.
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