Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Trillium Health Partners, Mississauga, Ontario, Canada.
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00900-18. Print 2018 Sep.
In this retrospective study of 285 patients receiving outpatient parenteral antibiotic therapy (OPAT), the duration of antibiotic, use of double-lumen catheters, and receipt of penicillin G and cloxacillin appeared to increase the risk of peripherally inserted central catheter (PICC) occlusion. Physicians should consider these factors when prescribing long-term antibiotic therapy. Further studies are needed to evaluate methods to reduce PICC occlusion, particularly when double-lumen PICCs are necessary and when cloxacillin or penicillin G are the preferred treatment.
在这项对 285 名接受门诊肠外抗生素治疗 (OPAT) 的患者进行的回顾性研究中，抗生素使用时间、双腔导管使用以及青霉素 G 和氯唑西林的使用似乎增加了经外周中心静脉置管 (PICC) 堵塞的风险。医生在开长期抗生素治疗时应考虑这些因素。需要进一步研究以评估减少 PICC 堵塞的方法，特别是在需要使用双腔 PICC 且首选治疗药物为氯唑西林或青霉素 G 时。
