不同收入和种族背景的1型糖尿病患儿的压力、糖尿病困扰与生物标志物之间的关系
Relationships Among Stress, Diabetes Distress, and Biomarkers in Children with Type 1 Diabetes Mellitus from Diverse Income and Racial Backgrounds.
作者信息
Davis Sara L, Jaser Sarah S, Ivankova Nataliya, Rice Marti
出版信息
J Pediatr Health Care. 2025 Jan-Feb;39(1):5-13. doi: 10.1016/j.pedhc.2024.08.012. Epub 2024 Oct 10.
INTRODUCTION
The purpose of this quantitative study was to consider factors that may negatively impact glycemic levels in Black and White children 8-12 years old with a diagnosis of type 1 diabetes mellitus.
METHOD
Perceived stress, diabetes distress, morning and afternoon salivary cortisol, inflammatory biomarkers, and hemoglobin A1c (HbA1c) were measured in this quantitative, cross-sectional phase of a larger, mixed methods study. Thirty-four children and their parents completed self-report surveys, and children provided blood and salivary samples, to examine effect sizes of relationships among variables of interest.
RESULTS
Most children did not meet ADA recommendations for HbA1c. HbA1c was higher in Black children. Medium-to-large effects were noted between perceived stress and HbA1c. Cortisol and IL-8 may mediate the relationship between perceived stress and HbA1c in children.
DISCUSSION
Understanding causes of elevated glycemic levels in children, especially from low-income and underrepresented populations, may help tailor diabetes management interventions to improve health outcomes.
引言
这项定量研究的目的是探讨可能对8至12岁被诊断为1型糖尿病的黑人和白人儿童血糖水平产生负面影响的因素。
方法
在一项更大规模的混合方法研究的这个定量横断面阶段，测量了感知压力、糖尿病困扰、上午和下午的唾液皮质醇、炎症生物标志物以及糖化血红蛋白（HbA1c）。34名儿童及其父母完成了自我报告调查，儿童提供了血液和唾液样本，以检验感兴趣变量之间关系的效应大小。
结果
大多数儿童的HbA1c未达到美国糖尿病协会的建议。黑人儿童的HbA1c更高。在感知压力和HbA1c之间观察到中等至较大的效应。皮质醇和白细胞介素-8可能介导儿童感知压力与HbA1c之间的关系。
讨论
了解儿童血糖水平升高的原因，尤其是来自低收入和代表性不足人群的儿童，可能有助于制定糖尿病管理干预措施以改善健康结果。
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