大脑与眼睛的联系：不仅仅是动作电位。

The brain-eye connection: More than just action potentials.

机构信息

John F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, USA.

出版信息

J Exp Med. 2024 Nov 4;221(11). doi: 10.1084/jem.20241519. Epub 2024 Oct 10.

DOI:10.1084/jem.20241519

PMID:39387899

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11471833/

Abstract

In this issue of the Journal of Experimental Medicine, Cao et al. (https://doi.org/10.1084/jem.20240386) demonstrate that the connection between the eye and the brain goes beyond the impulses carried by the optic nerve and that in Alzheimer's disease (AD), the influx of toxic Aβ from the brain to the retina underlies AD-induced retinal degeneration.

摘要

在本期《实验医学杂志》中，曹等人（https://doi.org/10.1084/jem.20240386）表明，眼睛和大脑之间的联系不仅仅局限于视神经传递的冲动，而且在阿尔茨海默病（AD）中，AD 诱导的视网膜变性的基础是大脑中有毒的 Aβ 向视网膜的流入。