年轻女性肛肠畸形手术后的性功能和生育能力。
Sexual function and fertility in young female adults surgically treated for anorectal malformations.
机构信息
Unit of Pediatric Surgery, Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Eugeniavägen C11:33 Solna, 17176, Stockholm, Sweden.
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
出版信息
Pediatr Surg Int. 2024 Oct 10;40(1):269. doi: 10.1007/s00383-024-05847-1.
PURPOSE
The aim was to investigate sexual function and fertility in female adults operated on for anorectal malformations (ARM).
METHODS
This was a cross-sectional questionnaire-based study including female adult patients treated for ARM at our institution between 1994 and 2003. Sexual function in females was assessed using the Profile of Sexual Function (PFSF). Additional questions regarding fertility were answered by the participants. Patient characteristics were retrospectively retrieved from the medical records and descriptive statistics were used for analysis. Sexual function outcomes were compared to a control group from a previously published group of females. Composite outcome analysis was performed using previously published data to determine the potential impact of bowel function and health-related quality of life on sexual function. The ethics review authorities approved the study.
RESULTS
A total of 14 of 30 (46.7%) females responded to the questionnaires and had a mean age of 21.1 years (range 18-26). No association was found between PFSF and age or bowel function (Bowel Function Score), however, a strong correlation was found between PFSF and health-related quality of life (HRQoL) with a Spearman correlation of ρ 0.82 (p = 0.0011). The general satisfaction question was strongly associated with their total PFSF score (ρ = 0.71, p = 0.0092). Except for the "desire" item, the females in this cohort did not have significantly worse sexual function than the control population(p = 0.015). Ten of fourteen (71.4%) females had had their sexual debut at a mean age of 16.3 years and two of these women (20%) have been pregnant. All females had had menarche at a mean age of 12.7 years.
CONCLUSION
Sexual function in adult females was comparable to healthy controls except for the "desire" item where the cohort reported poorer outcomes. The cohort's sexual function had a direct association with their reported HRQoL where individuals with worse HRQoL also reported poorer sexual function.
LEVEL OF EVIDENCE
III.
目的
本研究旨在调查接受肛门直肠畸形（ARM）治疗的女性成年人的性功能和生育能力。
方法
这是一项基于问卷调查的横断面研究，纳入了 1994 年至 2003 年在我院接受 ARM 治疗的成年女性患者。采用性功能量表（PFSF）评估女性的性功能。参与者还回答了有关生育能力的其他问题。从病历中回顾性检索患者特征，并使用描述性统计进行分析。将性功能结果与之前发表的女性组的对照组进行比较。使用之前发表的数据进行综合结果分析，以确定肠功能和健康相关生活质量对性功能的潜在影响。伦理审查机构批准了该研究。
结果
共有 30 名女性中的 14 名（46.7%）回答了问卷，平均年龄为 21.1 岁（18-26 岁）。PFSF 与年龄或肠功能（肠功能评分）之间无关联，但 PFSF 与健康相关生活质量（HRQoL）之间存在很强的相关性，Spearman 相关系数为 ρ0.82（p=0.0011）。总体满意度问题与他们的总 PFSF 评分密切相关（ρ=0.71，p=0.0092）。除“欲望”项目外，该队列的女性性功能与对照组相比无显著差异（p=0.015）。14 名女性中有 10 名（71.4%）在平均年龄为 16.3 岁时开始性生活，其中 2 名女性（20%）怀孕。所有女性的初潮年龄平均为 12.7 岁。
结论
除了“欲望”项目外，成年女性的性功能与健康对照组相当，该队列报告的结果较差。该队列的性功能与其报告的 HRQoL 直接相关，HRQoL 较差的个体也报告性功能较差。
证据水平
III。
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