Department of Neuroscience, Azienda Ospedaliera San Camilo Forlanini, Rome, Italy.
NeuroOphthalmology Unit, Presidio Ospedaliero Oftalmico, Rome, Italy.
Neurol Sci. 2024 Dec;45(12):5929-5932. doi: 10.1007/s10072-024-07800-5. Epub 2024 Oct 10.
Ibuprofen, a commonly used over-the-counter medication, is widely recognized for its effective pain relief properties but is also associated with various adverse effects, including rare ocular and neurological manifestations. We report a case of a 27-year-old male who experienced transient vertical diplopia following a standard ibuprofen dosage for back pain. Symptoms resolved promptly upon discontinuation of the drug, with normal findings on extensive clinical and laboratory evaluations. The clinical presentation, suggestive of skew deviation, implies central toxicity. This case underscores the potential for diplopia associated with NSAIDs like ibuprofen to be underdiagnosed and offers valuable insights into the central toxicity of ibuprofen. Further research is warranted to elucidate the underlying mechanisms and optimize patient care in similar scenarios.
布洛芬是一种常用的非处方药物，因其具有有效的止痛特性而广为人知，但也与各种不良反应有关，包括罕见的眼部和神经系统表现。我们报告了一例 27 岁男性病例，他在服用标准剂量的布洛芬治疗背痛后出现短暂的垂直复视。停药后症状迅速缓解，广泛的临床和实验室检查未见异常。该病例的临床表现提示为斜视偏差，暗示存在中枢毒性。该病例强调了与布洛芬等 NSAIDs 相关的复视可能被漏诊，并为布洛芬的中枢毒性提供了有价值的见解。需要进一步研究以阐明潜在机制，并优化类似情况下的患者护理。
