Cinkilli Aktağ Esra, Yalçin Sıddika Songül, Yіrün Anıl, Balci Özyurt Aylin, Erkekoğlu Pınar
Department of Social Pediatrics, Institute of Child Health, Hacettepe University, Ankara, Türkiye.
Pediatric health and outpatient clinic, Lösante Hospital, Ankara, Türkiye.
Int J Environ Health Res. 2025 Jul;35(7):1870-1882. doi: 10.1080/09603123.2024.2412118. Epub 2024 Oct 10.
Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk 25(OH) vitamin D was measured by the competitive enzyme-linked immunosorbent assay method, and BPA was analyzed by fluorescence detector high pressure liquid chromatography technique. Multiple logistic regression analysis were performed for association. Among 70 lactating mothers, the median 25(OH) vitamin D level was 12.6 ng/mL. In 92.9% of breastmilk samples, detectable levels of BPA were found, with a median BPA concentration of 2.56 ng/mL. However, both univariate and multivariate analyses failed to reveal any association between breastmilk BPA and 25(OH) vitamin D levels. This lack of association in healthy lactating mothers, highlighting the need for further research to comprehensively understand the intricate dynamics of these factors.
双酚A（BPA）对人体健康有负面影响。本研究旨在探讨母乳中双酚A水平与25（OH）维生素D之间的关联。双酚A暴露情况和维生素D来源记录在研究表格上。母乳中25（OH）维生素D采用竞争性酶联免疫吸附测定法进行测定，双酚A通过荧光检测器高压液相色谱技术进行分析。对关联进行多因素逻辑回归分析。在70名哺乳期母亲中，25（OH）维生素D水平的中位数为12.6 ng/mL。在92.9%的母乳样本中检测到了可检测水平的双酚A，双酚A浓度中位数为2.56 ng/mL。然而，单因素和多因素分析均未发现母乳中双酚A与25（OH）维生素D水平之间存在任何关联。健康哺乳期母亲中这种缺乏关联的情况，凸显了进一步研究以全面了解这些因素复杂动态的必要性。
