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双重配体受体调控植物免疫和激素反应，并被线虫效应子靶向。

A receptor for dual ligands governs plant immunity and hormone response and is targeted by a nematode effector.

机构信息

Department of Plant Sciences, University of Idaho, Moscow, ID 83844.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Department of Genetics, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.

出版信息

Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2412016121. doi: 10.1073/pnas.2412016121. Epub 2024 Oct 10.

DOI:10.1073/pnas.2412016121
PMID:39388275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11494329/
Abstract

In this study, we show that the potato () pattern recognition receptor (PRR) NEMATODE-INDUCED LEUCINE-RICH REPEAT (LRR)-RLK1 (StNILR1) functions as a dual receptor, recognizing both nematode-associated molecular pattern ascaroside #18 (Ascr18) and plant hormone brassinosteroid (BR) to activate two different physiological outputs: pattern-triggered immunity (PTI) and BR response. Ascr18/BR-StNILR1 signaling requires the coreceptor potato BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (StBAK1) and perception of either ligand strengthens StNILR1 interaction with StBAK1 in plant cells. Significantly, the parasitically successful potato cyst nematode () utilizes the effector RHA1B, which is a functional ubiquitin ligase, to target StNILR1 for ubiquitination-mediated proteasome-dependent degradation, thereby countering Ascr18/BR-StNILR1-mediated PTI in potato and facilitating nematode parasitism. These findings broaden our understanding of PRR specificity and reveal a nematode parasitic mechanism that targets a PTI signaling pathway.

摘要

在这项研究中，我们表明，马铃薯（）模式识别受体（PRR）线虫诱导亮氨酸丰富重复（LRR）-RLK1（StNILR1）作为双重受体，识别线虫相关分子模式阿曲霉素#18（Ascr18）和植物激素油菜素内酯（BR），以激活两种不同的生理输出：模式触发免疫（PTI）和 BR 反应。Ascr18/BR-StNILR1 信号需要马铃薯油菜素内酯不敏感 1 相关受体激酶 1（StBAK1）的核心受体，并且对任一配体的感知都会增强植物细胞中 StNILR1 与 StBAK1 的相互作用。重要的是，寄生成功的马铃薯胞囊线虫（）利用效应因子 RHA1B，它是一种功能性泛素连接酶，靶向 StNILR1 进行泛素化介导的蛋白酶体依赖性降解，从而抵消 Ascr18/BR-StNILR1 介导的马铃薯 PTI，并促进线虫寄生。这些发现拓宽了我们对 PRR 特异性的理解，并揭示了一种线虫寄生机制，该机制针对 PTI 信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/91ecbf67572e/pnas.2412016121fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/512f9e1910b9/pnas.2412016121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/da39b9043d7a/pnas.2412016121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/57b524dcf818/pnas.2412016121fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/de31d7073112/pnas.2412016121fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/91ecbf67572e/pnas.2412016121fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/512f9e1910b9/pnas.2412016121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/da39b9043d7a/pnas.2412016121fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/57b524dcf818/pnas.2412016121fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/de31d7073112/pnas.2412016121fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246f/11494329/91ecbf67572e/pnas.2412016121fig05.jpg

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