Bowden C P, James A M
Microbios. 1985;44(179-180):201-16.
The addition of nalidixic acid (NA) to exponentially growing cells of Klebsiella aerogenes in simple salts/glucose media has a marked effect on the thermal and other growth parameters of the cells. Mass and energy balances have been established for normal and inhibited growth. The decrease, with increasing NA concentration, of energy allocated to biomass and the increase in that wasted is discussed in terms of the energy stored in macromolecular species by the cells under conditions of stress. The enthalpy of production of cellular material, and the enthalpy of metabolism of glucose become more negative with increasing inhibition. A dual-dose response of NA was observed; at low concentrations the potency was greater than at high concentrations.
在简单盐类/葡萄糖培养基中，向指数生长期的产气克雷伯菌细胞添加萘啶酸（NA），会对细胞的热生长参数及其他生长参数产生显著影响。已针对正常生长和受抑制生长建立了质量和能量平衡。根据细胞在应激条件下储存在大分子物质中的能量，讨论了随着NA浓度增加，分配给生物量的能量减少以及浪费的能量增加的情况。随着抑制作用增强，细胞物质产生的焓以及葡萄糖代谢的焓变得更负。观察到NA的双剂量反应；低浓度时的效力高于高浓度时。
