区域发散性自由基接力烯烃双碳官能团化

Liu Zhong, D'Amico Francesco, Martin Ruben

The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.

Department of Biotechnology, Chemistry and Pharmacy University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

J Am Chem Soc. 2024 Oct 23;146(42):28624-28629. doi: 10.1021/jacs.4c10204. Epub 2024 Oct 10.

Herein, we report a regiodivergent 1,n-dicarbofunctionalization of unactivated olefins enabled by a Ni-catalyzed radical relay that forges both C()-C() and C()-C() linkages, even at long-range. Initial studies support an intertwined scenario resulting from the merger of an atom-transfer radical addition (ATRA) and a chain-walking event, with site-selectivity being dictated by a judicious choice of the ligand backbone.

在此，我们报道了一种由镍催化的自由基接力实现的未活化烯烃的区域发散性1,n-二碳官能团化反应，该反应能构建C（）-C（）和C（）-C（）键，即使是长距离的键。初步研究支持了一种由原子转移自由基加成（ATRA）和链行走事件合并产生的交织情景，位点选择性由配体骨架的明智选择决定。