Department of Medicine, Molecular Pharmacology and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Cell Host Microbe. 2024 Oct 9;32(10):1637-1639. doi: 10.1016/j.chom.2024.09.003.
A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
最近发表在《自然》杂志上的一篇论文揭示,肠道微生物将 N-丁基-N-(4-羟基丁基)亚硝胺(BBN)代谢为肠道中的膀胱致癌物质 N-正丁基-N-(3-羧基丙基)亚硝胺(BCPN),在肠道微生物活动与膀胱癌发展之间建立了直接联系。