Department of Dermatology, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Institute of Virology and AIDS Research, First Hospital, Jilin University, Changchun, Jilin, 130021, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Cell Host Microbe. 2024 Oct 9;32(10):1645-1648. doi: 10.1016/j.chom.2024.09.001.
Recent findings suggest that HIV-1 capsids mimic nuclear transport receptors to engage FG-nucleoporins for entry into host nuclei. In this issue of Cell Host & Microbe, Moschonas et al. report that MX2 forms cytoplasmic condensates comprising FG-nucleoporins resembling nuclear pore complexes to capture viral capsids and hinder their nuclear transport.
最近的研究结果表明，HIV-1 衣壳模拟核转运受体，与 FG-核孔蛋白结合，从而进入宿主细胞核。在本期《细胞宿主与微生物》杂志中，Moschonas 等人报告称，MX2 形成包含 FG-核孔蛋白的细胞质凝聚物，类似于核孔复合物，以捕获病毒衣壳并阻止其核运输。
