拟态游戏：类 NPC 的 MX2 凝聚体捕获病毒。
Mimicry games: NPC-like MX2 condensates trap viruses.
机构信息
Department of Dermatology, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
Institute of Virology and AIDS Research, First Hospital, Jilin University, Changchun, Jilin, 130021, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
出版信息
Cell Host Microbe. 2024 Oct 9;32(10):1645-1648. doi: 10.1016/j.chom.2024.09.001.
Recent findings suggest that HIV-1 capsids mimic nuclear transport receptors to engage FG-nucleoporins for entry into host nuclei. In this issue of Cell Host & Microbe, Moschonas et al. report that MX2 forms cytoplasmic condensates comprising FG-nucleoporins resembling nuclear pore complexes to capture viral capsids and hinder their nuclear transport.
最近的研究结果表明，HIV-1 衣壳模拟核转运受体，与 FG-核孔蛋白结合，从而进入宿主细胞核。在本期《细胞宿主与微生物》杂志中，Moschonas 等人报告称，MX2 形成包含 FG-核孔蛋白的细胞质凝聚物，类似于核孔复合物，以捕获病毒衣壳并阻止其核运输。
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