感知或不感知，潘氏细胞对黏膜免疫的调节。

To sense or not to sense, Paneth cell regulation of mucosal immunity.

机构信息

Institute for Infectious Disease and Infection Control, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), 07745 Jena, Germany.

Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, QC, Canada; McGill Regenerative Medicine Network, Montreal, QC, Canada; McGill Centre for Microbiome Research, Montreal, QC, Canada.

出版信息

Cell Host Microbe. 2024 Oct 9;32(10):1648-1650. doi: 10.1016/j.chom.2024.09.005.

DOI:10.1016/j.chom.2024.09.005

PMID:39389028

Abstract

Paneth cells located within intestinal crypts support epithelial stem cells and immunity through growth factors and antimicrobial peptides. In this issue of Cell Host & Microbe, Wallaeys et al. report that TNF sensing by Paneth cells disrupts the unfolded protein response and decreases antimicrobial peptides, causing bacterial translocation and sepsis.

摘要

位于肠隐窝内的潘氏细胞通过生长因子和抗菌肽支持上皮干细胞和免疫。在本期《细胞宿主与微生物》中，Wallaey 等人报告称，潘氏细胞对 TNF 的感应会破坏未折叠蛋白反应并减少抗菌肽，从而导致细菌易位和败血症。