Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai Yuhuangding Hospital, Yantai, China; Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding Hospital, Yantai, China.
Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai Yuhuangding Hospital, Yantai, China; Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding Hospital, Yantai, China; Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Neurobiol Dis. 2024 Nov;202:106690. doi: 10.1016/j.nbd.2024.106690. Epub 2024 Oct 9.
The nose-brain axis (NBA), a critical component of the body-brain axis, not only serves as a drug transport route for the treatment of brain diseases but also mediates changes such as neuroimmune disorders, which may be an important mechanism in the occurrence and development of some nasal or brain diseases. Despite its importance, there are substantial gaps that remain in our understanding of the characteristics of NBA-mediated diseases and of the cellular and molecular mechanisms underlying the bidirectional NBA crosstalk. These gaps have limited the translational application of NBA-related research findings to some extent. Therefore, this review aims to address the conceptual framework of NBA and highlight its values in representative diseases by combining existing literature with new research results from our group. We hope that this paper will provide a basis for further in-depth research in this field, and facilitate the clinical translation of NBA.
鼻脑轴（NBA）是体脑轴的一个关键组成部分，不仅作为治疗脑部疾病的药物传输途径，还介导神经免疫紊乱等变化，这可能是某些鼻或脑部疾病发生和发展的一个重要机制。尽管其重要性不言而喻，但我们对于 NBA 介导的疾病特征以及双向 NBA 串扰背后的细胞和分子机制的理解仍存在很大的空白。这些空白在一定程度上限制了 NBA 相关研究发现的转化应用。因此，本综述旨在通过结合现有文献和我们小组的新研究成果，阐述 NBA 的概念框架，并突出其在代表性疾病中的价值。我们希望本文能够为该领域的进一步深入研究提供基础，并促进 NBA 的临床转化。
