在类风湿性关节炎患者中，针对氨甲酰化纤维蛋白原α链的免疫反应性不会与瓜氨酸化纤维蛋白原免疫显性肽发生交叉反应。 - Suppr

Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis.

作者信息

Brevet Pauline, Boyer Olivier, Vittecoq Olivier, Fréret Manuel

机构信息

Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Rheumatology & CIC-CRB 1404, F-76000 Rouen, France

Univ Rouen Normandie, Inserm, Normandie Univ, PANTHER UMR 1234, CHU Rouen, Department of Immunology and Biotherapies, F-76000 Rouen, France.

出版信息

RMD Open. 2024 Oct 10;10(4):e004746. doi: 10.1136/rmdopen-2024-004746.

DOI:10.1136/rmdopen-2024-004746

PMID:39389619

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11474728/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3907/11474728/7bed94e4b73b/rmdopen-10-4-g001.jpg

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Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis.在类风湿性关节炎患者中，针对氨甲酰化纤维蛋白原α链的免疫反应性不会与瓜氨酸化纤维蛋白原免疫显性肽发生交叉反应。

RMD Open. 2024 Oct 10;10(4):e004746. doi: 10.1136/rmdopen-2024-004746.

Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies.抗氨甲酰化纤维蛋白原抗体可能与特定的类风湿表型相关，并包括一组识别其 γ 链表位的抗体，其中一个表位与抗瓜氨酸化蛋白抗体不交叉反应。

Front Immunol. 2021 Oct 7;12:733511. doi: 10.3389/fimmu.2021.733511. eCollection 2021.

Brief Report: Anti-Carbamylated Protein Antibodies in Rheumatoid Arthritis Patients Are Reactive With Specific Epitopes of the Human Fibrinogen β-Chain.简报：类风湿关节炎患者的抗瓜氨酸化蛋白抗体与人类纤维蛋白原β 链的特定表位反应。

Arthritis Rheumatol. 2017 Jul;69(7):1381-1386. doi: 10.1002/art.40098. Epub 2017 Jun 5.

The Diagnostic Value of Antibodies Against Citrullinated or Carbamylated Fibrinogen in Rheumatoid Arthritis.抗瓜氨酸化或氨甲酰化纤维蛋白原抗体对类风湿关节炎的诊断价值。

Clin Lab. 2020 May 1;66(5). doi: 10.7754/Clin.Lab.2020.191256.

Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.鉴定瓜氨酸化肌腱蛋白-C中的一个免疫显性肽作为类风湿关节炎自身抗体的主要靶点。

Ann Rheum Dis. 2016 Oct;75(10):1876-83. doi: 10.1136/annrheumdis-2015-208495. Epub 2015 Dec 9.

Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells.类风湿关节炎中对新鉴定的瓜氨酸化纤维蛋白原肽的抗体反应及相应B细胞的可视化

Arthritis Res Ther. 2016 Dec 1;18(1):284. doi: 10.1186/s13075-016-1181-0.

Citrullination facilitates cross-reactivity of rheumatoid factor with non-IgG1 Fc epitopes in rheumatoid arthritis.瓜氨酸化促进类风湿因子与类风湿关节炎中非 IgG1 Fc 表位的交叉反应。

Sci Rep. 2019 Aug 19;9(1):12068. doi: 10.1038/s41598-019-48176-3.

In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein-Barr nuclear antigen-1, strongly cross-react with the peptide β60-74Cit which bears the immunodominant epitope of citrullinated fibrin.在抗环瓜氨酸肽抗体（ACPA）阳性的类风湿关节炎（RA）患者中，针对EBNA35 - 58Cit（一种来自EB病毒核抗原-1的瓜氨酸化肽）的抗体与带有瓜氨酸化纤维蛋白免疫显性表位的肽β60 - 74Cit发生强烈交叉反应。

Immunol Res. 2015 Feb;61(1-2):117-25. doi: 10.1007/s12026-014-8584-2.

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation.翻译：翻译后修饰在类风湿关节炎发病机制中的作用：聚焦瓜氨酸化、氨甲酰化和乙酰化。

Int J Mol Sci. 2021 Sep 30;22(19):10576. doi: 10.3390/ijms221910576.

The fibrin-derived citrullinated peptide β60-74Cit₆₀,₇₂,₇₄ bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies.纤维蛋白衍生的瓜氨酸化肽β60-74Cit₆₀,₇₂,₇₄ 携带类风湿关节炎特异性抗瓜氨酸化纤维蛋白原自身抗体和抗-CCP2 抗体识别的主要 ACPA 表位。

Ann Rheum Dis. 2014 Jun;73(6):1246-52. doi: 10.1136/annrheumdis-2012-202868. Epub 2013 May 1.

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Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays.深入了解AMPA交叉反应性的检测：比较基于环肽和基于蛋白质的检测方法。

Arthritis Res Ther. 2025 Jul 7;27(1):138. doi: 10.1186/s13075-025-03591-y.

本文引用的文献

Front Immunol. 2021 Oct 7;12:733511. doi: 10.3389/fimmu.2021.733511. eCollection 2021.

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.识别瓜氨酸化蛋白的抗体和 B 细胞对其他翻译后修饰表现出广泛的交叉反应性。

Ann Rheum Dis. 2020 Apr;79(4):472-480. doi: 10.1136/annrheumdis-2019-216499. Epub 2020 Feb 10.

Affinity Maturation of the Anti-Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis.抗瓜氨酸化蛋白抗体表位的亲和成熟驱动类风湿关节炎中的表位扩展和多反应性。

Arthritis Rheumatol. 2019 Apr;71(4):507-517. doi: 10.1002/art.40760. Epub 2019 Feb 27.

Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage.类风湿关节炎症状前期的抗瓜氨酸化蛋白抗体、它们与多种抗瓜氨酸肽抗体的关系以及与放射学损伤的关联

Arthritis Res Ther. 2015 Feb 7;17(1):25. doi: 10.1186/s13075-015-0536-2.

Ann Rheum Dis. 2014 Jun;73(6):1246-52. doi: 10.1136/annrheumdis-2012-202868. Epub 2013 May 1.

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.自身抗体识别氨基甲酰化蛋白存在于类风湿关节炎患者的血清中，并可预测关节损伤。

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17372-7. doi: 10.1073/pnas.1114465108. Epub 2011 Oct 10.

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Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis.

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