Delic J I, Hendry J H, Morris I D, Shalet S M
Radiother Oncol. 1986 Jan;5(1):39-45. doi: 10.1016/s0167-8140(86)80007-x.
The dose- and time-related responses of the irradiated seminiferous epithelium in the pubertal rat have been investigated. The threshold dose for Sertoli cell dysfunction, as assessed by serum androgen binding protein (ABP) concentrations, was estimated to be 5 Gy. A significant reduction (to less than 50% of control levels) in serum ABP was observed at 8 weeks post-irradiation, with further reductions at later times (24 and 36 weeks). Serum follicle-stimulating hormone (FSH) was elevated to between 130 and 175% of control at only 2 weeks post-irradiation, but recovered with time. Normal FSH levels seemed to be related to recovery of spermatogenesis, as assessed by counts of regenerating tubule cross-sections. The results indicate that the clonogenic spermatogonia and Sertoli cells of the pubertal rat testis are less sensitive to radiation than those of the adult.
已对青春期大鼠受辐照的生精上皮的剂量和时间相关反应进行了研究。通过血清雄激素结合蛋白（ABP）浓度评估，支持细胞功能障碍的阈剂量估计为5 Gy。辐照后8周时观察到血清ABP显著降低（降至对照水平的50%以下），在之后的时间（24周和36周）进一步降低。血清促卵泡激素（FSH）仅在辐照后2周时升高至对照水平的130%至175%，但随时间恢复。通过再生小管横截面积计数评估，正常FSH水平似乎与生精作用的恢复有关。结果表明，青春期大鼠睾丸的克隆性精原细胞和支持细胞对辐射的敏感性低于成年大鼠。
