Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, 56212, Republic of Korea.
Department of Food Science and Technology, Graduate School of Chonnam National University, Gwangju, 61186, Republic of Korea.
BMC Microbiol. 2024 Oct 10;24(1):404. doi: 10.1186/s12866-024-03536-6.
Preventing post-weaning diarrhea (PWD) in weaned piglets is a crucial challenge in the swine production industry. The stress of weaning, dietary shifts from maternal milk to solid feed, and environmental changes lead to decreased microbial diversity, increased pathogen abundance, and compromised intestinal integrity. We have previously identified Lactiplantibacillus argentoratensis AGMB00912 (LA) in healthy porcine feces, which demonstrated antimicrobial activity against pathogens and enhanced short-chain fatty acid production. This research aimed to evaluate the efficacy of LA strain supplementation as a strategy to inhibit PWD and enhance overall growth performance in weaned piglets.
LA supplementation in weaned piglets significantly increased body weight gain, average daily gain, and average daily feed intake. It also alleviated diarrhea symptoms (diarrhea score and incidence). Notably, LA was found to enrich beneficial microbial populations (Lactobacillus, Anaerobutyricum, Roseburia, Lachnospiraceae, and Blautia) while reducing the abundance of harmful bacteria (Helicobacter and Campylobacter). This not only reduces the direct impact of pathogens but also improves the overall gut microbiota structure, thus enhancing the resilience of weaned piglets. LA treatment also promotes the growth of the small intestinal epithelial structure, strengthens gut barrier integrity, and increases short-chain fatty acid levels in the gut.
The study findings demonstrate the promising potential of LA in preventing PWD. Supplementation with the LA strain offers a promising feed additive for improving intestinal health and growth in piglets during the weaning transition, with the potential to significantly reduce the incidence and severity of PWD.
预防断奶后腹泻（PWD）是生猪生产行业面临的一项重大挑战。断奶应激、由母乳向固体饲料的饮食转变以及环境变化会导致微生物多样性减少、病原体丰度增加和肠道完整性受损。我们之前在健康猪粪便中发现了植物乳杆菌 AGMB00912（LA），其对病原体具有抗菌活性，并能促进短链脂肪酸的产生。本研究旨在评估 LA 菌株补充剂作为一种抑制 PWD 并提高断奶仔猪整体生长性能的策略的功效。
LA 补充剂显著增加了断奶仔猪的体重增加、平均日增重和平均日采食量。它还缓解了腹泻症状（腹泻评分和发病率）。值得注意的是，LA 被发现可富集有益微生物群（乳杆菌、厌氧棒状菌、罗斯伯里氏菌、lachnospiraceae 和布劳特氏菌），同时减少有害细菌（幽门螺杆菌和弯曲杆菌）的丰度。这不仅降低了病原体的直接影响，还改善了整体肠道微生物群落结构，从而增强了断奶仔猪的抵抗力。LA 处理还促进了小肠上皮结构的生长，增强了肠道屏障的完整性，并增加了肠道中的短链脂肪酸水平。
研究结果表明，LA 在预防 PWD 方面具有广阔的应用前景。LA 菌株的补充为改善仔猪在断奶过渡期间的肠道健康和生长提供了一种有前景的饲料添加剂，有望显著降低 PWD 的发病率和严重程度。
